slightly off topic but is 7.5 really the sweet spot or is that just channel folklore
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
titrate slow
held 10 for 2 months and lost 17kg over that stretch, slow and boring and fine
does the GIP arm actually explain the easier nausea or is that hand waving
no clean conversion
anyone stopped at 10 and stayed there for months
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
plateaued at 5 weeks the same way i did on semaglutide, so i doubt its compound specific, i could be wrong
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
10 was enough
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
start low anyway
at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
did anyone go past 15 and was there any point to it
i sat at 7.5 for 21 months and never needed more, which is where the folklore comes from
im at 2.5 and thinking about 15, did anyone gain anything from that step
the 2.5 to 5 step was the roughest one for me and everything after was easier
€94 for a 5 vial is roughly what ive paid for the last year
12 did nothing extra over 10 for me and that still holds a year later
at 15 the GI came back for me, so my easier profile claim only applies below that, ymmv
coming off semaglutide, is there a conversion or do i restart at 2.5
folklore probably
does the appetite effect feel different or just stronger
no gap when i switched, took the last semaglutide dose and started this a week later
my VendorInvestigate result on a Homopeptide vial came in at 98.6 which is why i keep buying from them
did going from 12 semaglutide to 5 of this feel like a step down for anyone
same plateau here
easier gi for me
at 2.5 my appetite is gone entirely, did anyone go down rather than up
coming back to this did anybody switch back to semaglutide after trying this