does the GIP arm actually explain the easier nausea or is that hand waving
#tirzepatide 2025-10-04
Saturday45 messages9 participantstimes are UTC
Highlights from this day
went back to semaglutide after 21 months because the cost difference mattered more than the GI
no gap when i switched, took the last semaglutide dose and started this a week later
anyone got a 8 recon they like for the 40 vials
anyone stopped at 10 and stayed there for months
unrelated but is there a reason to titrate slower than the four week schedule
how long before the dual thing was noticeable to you
follow up why does everyone talk about 7.5 and not 10
is the 20 vial the common one or do people use 2
my Janoshik result on a ERP vial came in at 99.2 which is why i keep buying from them
checked the units twice
how did people handle the 2.5 to 5 jump
7.5 gang
easier gi for me
follow up the 20 vial in 2ml gives 2mg/ml which puts 10 on 12 units, nice round numbers
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
🧊8✅2
the GI difference held for me right up to 15, which isnt what a couple of people here found
🎉9✅12
follow up SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
folklore probably
did anyone find the GI easier than semaglutide at an equivalent effect
Purity check: no report on file for lot C-4402. Nothing logged either way.
🎉18
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
🔥1
15 is the top
im at 2 and thinking about 12, did anyone gain anything from that step
⚠️8💀1
the sweet spot argument is really about effect per side effect, not a magic number
at 15 the GI came back for me, so my easier profile claim only applies below that, thats one data point
the switch felt like a step down at first and then caught up around week 24
12 did nothing extra over 10 for me and that still holds a year later
£94 for a 15 vial is roughly what ive paid for the last year
$38 for a 40 vial is roughly what ive paid for the last year
plateaued at 5 weeks the same way i did on semaglutide, so i doubt its compound specific
there is no clean conversion between the two, anyone giving you a ratio is guessing
did anybody switch back to semaglutide after trying this
the sweet spot thing is survivorship, the people it worked for stayed and said so
10 was enough
titrate slow
🔥1
is SURMOUNT-OSA the sleep apnoea one
my PeptideMeter result on a CPC vial came in at 99.4 which is why i keep buying from them
i argued the sweet spot was nonsense and then spent 3 months at 7.5 not needing more
coming off semaglutide, is there a conversion or do i restart at 2.5
back after 1 months, do i restart at 2.5 or pick up near where i left off
🧪15🤝7
5 was where i first noticed it properly, 2.5 did almost nothing for me
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
while im here is the sweet spot argument about effect or about side effects