if youre coming off semaglutide the honest answer is start low and find out, theres no table
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#tirzepatide 2026-02-05
Thursday56 messages13 participantstimes are UTC
Highlights from this day
- seven_five_sweet — if youre coming off semaglutide the honest answer is start low and find out, theres no table 18:36
- net_peptide — at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win 20:00
- per_mg_pete — €72 for a 10 vial is roughly what ive paid for the last year 21:01
5 was where i first noticed it properly, 2.5 did almost nothing for me
checked the units twice
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i went to 15 and came back to 10, more suppression wasnt more useful for me
right so back after 22 months, do i restart at 2.5 or pick up near where i left off
transit-times.csv
561 rows · not retained in the public archive
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
quick one did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
does switching from semaglutide need a gap or do you just start
anyone tracked whether the GI difference held at the top doses
*Janoshik not the other one
ok so at 15 the GI came back for me, so my easier profile claim only applies below that
restarted at 2.5 after 9 months off and the first two doses reminded me why titration exists
whats the top licensed dose, 15 or does it go higher
went back to semaglutide after 25 months because the cost difference mattered more than the GI
does the GIP arm actually explain the easier nausea or is that hand waving
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
for the archive there is no clean conversion between the two, anyone giving you a ratio is guessing
anyone got a 8 recon they like for the 5 vials
5 did nothing
is SURMOUNT-OSA the sleep apnoea one
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
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coming back to this changed my mind about needing 15, i was chasing a number rather than an outcome
appetite_backSURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix…
update on the earlier thing SURMOUNT-1 versus SURPASS-2, which one was the weight trial
did anyone find the GI easier than semaglutide at an equivalent effect
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10 was enough
ok so my PeptideMeter result on a HJ vial came in at 98.6 which is why i keep buying from them
[redacted at member request] · archive policy
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15 is the top
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im at 1 and thinking about 1.7, did anyone gain anything from that step
easier gi for me
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held 10 for 1 months and lost 6kg over that stretch, slow and boring and fine
how many weeks at 7.5 before you knew it was enough
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is there a reason to titrate slower than the four week schedule
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follow up is 7.5 really the sweet spot or is that just channel folklore
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€72 for a 10 vial is roughly what ive paid for the last year
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)ok so how did people handle the 2.5 to 5 jump
titrate slow
same plateau here
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the 30 vial in 1ml gives 5mg/ml which puts 1.7 on 30 units, nice round numbers
12 did nothing extra over 10 for me and that still holds a year later
coming back to this the 2.5 to 5 step was the roughest one for me and everything after was easier
the switch felt like a step down at first and then caught up around week 29
the two compounds arent interchangeable week for week even if the effect ends up similar
the trials titrated every four weeks to a target, most people here stop at whatever works
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
no clean conversion
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
[redacted at member request] · archive policy
Inter-lab diff for lot F-1330: 99.2% vs 99.4%. Within expected range.
the sweet spot argument is really about effect per side effect, not a magic number
medutest-report-g-0641.pdf
3 pages · 201 KB · not retained in the public archive
start low anyway
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no gap when i switched, took the last semaglutide dose and started this a week later
i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more
GIP plus GLP-1