SURMOUNT-1 versus SURPASS-2, which one was the weight trial
#tirzepatide 2025-07-03
Thursday31 messages9 participantstimes are UTC
Highlights from this day
- no_appetite_nia — at 15 the GI came back for me, so my easier profile claim only applies below that, ill dig out the number 16:55
- lead_time_lars — my VendorInvestigate result on a HJ vial came in at 96.8 which is why i keep buying from them 17:28
- lead_time_lars — for the archive there is no clean conversion between the two, anyone giving you a ratio is guessing 17:43
- ghent_gradient — held 10 for 19 months and lost 6kg over that stretch, slow and boring and fine 18:46
checked the units twice
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, i have it written down somewhere
10 was enough
the two compounds arent interchangeable week for week even if the effect ends up similar
😂4
at 15 the GI came back for me, so my easier profile claim only applies below that, ill dig out the number
🧊7🎉3
anyone stopped at 10 and stayed there for months
SURMOUNT is weight
same plateau here
📈2
slightly off topic but switched from 5 semaglutide and started at 2.5, took the slow route, never regretted it
the trials titrated every four weeks to a target, most people here stop at whatever works, ill dig out the number
my VendorInvestigate result on a HJ vial came in at 96.8 which is why i keep buying from them
📈8
titrate slow
for the archive there is no clean conversion between the two, anyone giving you a ratio is guessing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
[redacted at member request] · archive policy
switched last year
went back to semaglutide after 10 months because the cost difference mattered more than the GI
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
does the GIP arm actually explain the easier nausea or is that hand waving
*VendorInvestigate not the other one
is the sweet spot argument about effect or about side effects
held 10 for 19 months and lost 6kg over that stretch, slow and boring and fine
🙏15📈4📉18
follow up licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
*week 2 not week 5
how long before the dual thing was noticeable to you
40 units of a 2 solution is a lot of volume and i check that one twice every single time
*that should say weekly
i went to 15 and came back to 10, more suppression wasnt more useful for me
easier gi for me
peptidemeter-summary-kp-0925.pdf
2 pages · 883 KB · not retained in the public archive
does the appetite effect feel different or just stronger
7.5 gang