at 2.5 my appetite is gone entirely, did anyone go down rather than up
#tirzepatide 2025-11-24
Monday48 messages8 participantstimes are UTC
Highlights from this day
- split_the_cost — the sweet spot argument is really about effect per side effect, not a magic number, i have it written down somewhere 21:11
- ferritin_fay — 12 did nothing extra over 10 for me and that still holds a year later 22:28
- hk_hplc — my Medutest result on a SWB vial came in at 98.6 which is why i keep buying from them 23:27
no clean conversion
i went to 15 and came back to 10, more suppression wasnt more useful for me, take that with a pinch of salt
anyone got a 2.5 recon they like for the 30 vials
the 20 vial in 2ml gives 5mg/ml which puts 0.25 on 40 units, nice round numbers, thats just me
how many weeks at 7.5 before you knew it was enough
changed my mind about needing 15, i was chasing a number rather than an outcome, take that with a pinch of salt
GIP plus GLP-1
is 7.5 really the sweet spot or is that just channel folklore
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
easier gi for me
is the 15 vial the common one or do people use 10
checked the units twice
did anyone go past 15 and was there any point to it
does the appetite effect feel different or just stronger
5 was where i first noticed it properly, 2.5 did almost nothing for me
went back to semaglutide after 13 months because the cost difference mattered more than the GI
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
whats the top licensed dose, 15 or does it go higher
👀8🔥3
i sat at 7.5 for 26 months and never needed more, which is where the folklore comes from
the sweet spot argument is really about effect per side effect, not a magic number, i have it written down somewhere
👍5⚠️3🧪16
how did people handle the 2.5 to 5 jump
update on the earlier thing did anyone find the GI easier than semaglutide at an equivalent effect
the switch felt like a step down at first and then caught up around week 20
did going from 5 semaglutide to 5 of this feel like a step down for anyone
whats the plateau pattern here, same as semaglutide or different
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
slightly off topic but licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, thats just me
✅2
switched last year
the 2.5 to 5 step was the roughest one for me and everything after was easier
the switch felt like a step down at first and then caught up around week 25
at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win
how long before the dual thing was noticeable to you
right so does the GIP arm actually explain the easier nausea or is that hand waving
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SURMOUNT is weight
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, thats just me
at 15 the GI came back for me, so my easier profile claim only applies below that
💀1📈7
update on the earlier thing the trials titrated every four weeks to a target, most people here stop at whatever works
12 did nothing extra over 10 for me and that still holds a year later
🧪10🔥2⚠️4
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
titrate slow
7.5 gang
start low anyway
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
there is no clean conversion between the two, anyone giving you a ratio is guessing, thats just me
i argued the sweet spot was nonsense and then spent 19 months at 7.5 not needing more
the GI difference held for me right up to 15, which isnt what a couple of people here found
👀1
15 is the top
my Medutest result on a SWB vial came in at 98.6 which is why i keep buying from them
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)