for the archive 12 did nothing extra over 10 for me and that still holds a year later
#tirzepatide 2025-10-21
Tuesday49 messages12 participantstimes are UTC
Highlights from this day
- VialBot — Verification log updated: GGPeps — evidence added, status unchanged. 19:08
- deadspace — there is no clean conversion between the two, anyone giving you a ratio is guessing went back to semaglutide after 11 months because the cost difference mattered more… 19:45
- coa_or_cope — back after 12 months, do i restart at 2.5 or pick up near where i left off 20:21
- leeds_ledger — i log everything and my appetite curve looks flatter across the week than my semaglutide log did, ymmv 21:28
- typosquat_tay — no gap when i switched, took the last semaglutide dose and started this a week later 21:54
held 10 for 14 months and lost 32kg over that stretch, slow and boring and fine
coming off semaglutide, is there a conversion or do i restart at 2.5
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
no clean conversion
Verification log updated: GGPeps — evidence added, status unchanged.
does the GIP arm actually explain the easier nausea or is that hand waving
titrate slow
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at 15 the GI came back for me, so my easier profile claim only applies below that
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whats the top licensed dose, 15 or does it go higher
the sweet spot argument is really about effect per side effect, not a magic number
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
plateaued at 23 weeks the same way i did on semaglutide, so i doubt its compound specific
19:37chlorhex pinned a message to this channel
[redacted at member request] · archive policy
there is no clean conversion between the two, anyone giving you a ratio is guessing
went back to semaglutide after 11 months because the cost difference mattered more than the GI
while im here how many weeks at 7.5 before you knew it was enough
why does everyone talk about 7.5 and not 10
start low anyway
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if youre coming off semaglutide the honest answer is start low and find out, theres no table
20:08chlorhex pinned a message to this channel
i went to 15 and came back to 10, more suppression wasnt more useful for me
SURMOUNT is weight
medutest-report-b-0329.pdf
3 pages · 925 KB · not retained in the public archive
the GI difference held for me right up to 15, which isnt what a couple of people here found
back after 12 months, do i restart at 2.5 or pick up near where i left off
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is there a reason to titrate slower than the four week schedule
folklore probably
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)$72 for a 20 vial is roughly what ive paid for the last year
checked the units twice
the 2.5 to 5 step was the roughest one for me and everything after was easier, still working it out
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the two compounds arent interchangeable week for week even if the effect ends up similar
easier gi for me
the sweet spot thing is survivorship, the people it worked for stayed and said so
same plateau here
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7.5 gang
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licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
5 did nothing
changed my mind about needing 15, i was chasing a number rather than an outcome
10 was enough
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, ymmv
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did anybody switch back to semaglutide after trying this
5 was where i first noticed it properly, 2.5 did almost nothing for me
i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more
switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
switched last year
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
40 units of a 2 solution is a lot of volume and i check that one twice every single time
no gap when i switched, took the last semaglutide dose and started this a week later
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)GIP plus GLP-1