the 2.5 to 5 step was the roughest one for me and everything after was easier, thats one data point
#tirzepatide 2025-07-21
Monday17 messages5 participantstimes are UTC
Highlights from this day
for the archive went back to semaglutide after 2 months because the cost difference mattered more than the GI
[edited]the sweet spot argument is really about effect per side effect, not a magic number
switched last year
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held 10 for 13 months and lost 38kg over that stretch, slow and boring and fine
40 units of a 8 solution is a lot of volume and i check that one twice every single time
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
*that should say weekly
the trials titrated every four weeks to a target, most people here stop at whatever works, someone check my working
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)plateaued at 34 weeks the same way i did on semaglutide, so i doubt its compound specific
Verification log updated: Homopeptide — evidence added, status unchanged.
✅5🧊4
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from, thats one data point
anyone got a 4 recon they like for the 20 vials
👀1📈18⚠️11
start low anyway
15 is the top
5 was where i first noticed it properly, 2.5 did almost nothing for me
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted