restarted at 2.5 after 20 months off and the first two doses reminded me why titration exists
🧊16
#tirzepatide 2026-01-11
Sunday49 messages11 participantstimes are UTC
Highlights from this day
titrate slow
[redacted at member request] · archive policy
did anyone go past 15 and was there any point to it
📈1🙏5🎉2
if youre coming off semaglutide the honest answer is start low and find out, theres no table
the 2.5 to 5 step was the roughest one for me and everything after was easier
the GI difference held for me right up to 15, which isnt what a couple of people here found
right so plateaued at 22 weeks the same way i did on semaglutide, so i doubt its compound specific
the 2 vial in 3ml gives 8mg/ml which puts 12 on 40 units, nice round numbers
i sat at 7.5 for 8 months and never needed more, which is where the folklore comes from
£94 for a 40 vial is roughly what ive paid for the last year
GIP plus GLP-1
whats the plateau pattern here, same as semaglutide or different
£240 for a 20 vial is roughly what ive paid for the last year
for the archive i argued the sweet spot was nonsense and then spent 13 months at 7.5 not needing more
is the sweet spot argument about effect or about side effects
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
the sweet spot thing is survivorship, the people it worked for stayed and said so
how many weeks at 7.5 before you knew it was enough
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
fridge-temps.csv
295 rows · not retained in the public archive
at 2 my appetite is gone entirely, did anyone go down rather than up
💀1⚠️1
is the 40 vial the common one or do people use 10
whats the top licensed dose, 15 or does it go higher
🎉15🙏12
10 was enough
no gap when i switched, took the last semaglutide dose and started this a week later
💀2
how did people handle the 2.5 to 5 jump
5 did nothing
does the GIP arm actually explain the easier nausea or is that hand waving
easier gi for me
same plateau here
✅6
changed my mind about needing 15, i was chasing a number rather than an outcome
held 10 for 2 months and lost 12kg over that stretch, slow and boring and fine, anyway
the switch felt like a step down at first and then caught up around week 3
there is no clean conversion between the two, anyone giving you a ratio is guessing
SURMOUNT is weight
12 did nothing extra over 10 for me and that still holds a year later
i went to 15 and came back to 10, more suppression wasnt more useful for me, n of 1 obviously
🙏14🔥17
for the archive switched from 1 semaglutide and started at 2.5, took the slow route, never regretted it
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
how long before the dual thing was noticeable to you
❤️11😂1👍1
coming off semaglutide, is there a conversion or do i restart at 2.5
genuine question is SURMOUNT-OSA the sleep apnoea one
7.5 gang
start low anyway
40 units of a 2 solution is a lot of volume and i check that one twice every single time
checked the units twice
at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
is there a reason to titrate slower than the four week schedule
why does everyone talk about 7.5 and not 10
🤝13💀6
genuine question 15 is the top