5 did nothing
#tirzepatide 2026-01-27
Tuesday50 messages9 participantstimes are UTC
Highlights from this day
- declared_value — my VendorInvestigate result on a ERP vial came in at 96.8 which is why i keep buying from them 18:26
- noct.titrate — the 30 vial in 2ml gives 10mg/ml which puts 12 on 40 units, nice round numbers, someone check my working 40 units of a 10 solution is a lot of volume and i check that… 18:37
- no_chargeback — at 15 my appetite went completely and i dropped back a step, eating nothing isnt a win 20:22
7.5 gang
10 was enough
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checked the units twice
coming off semaglutide, is there a conversion or do i restart at 2.5
switched last year
unrelated but GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
12 did nothing extra over 10 for me and that still holds a year later, someone check my working
held 10 for 13 months and lost 12kg over that stretch, slow and boring and fine
back after 19 months, do i restart at 2.5 or pick up near where i left off
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is SURMOUNT-OSA the sleep apnoea one
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whats the top licensed dose, 15 or does it go higher
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the 2 vial in 5ml gives 8mg/ml which puts 10 on 8 units, nice round numbers
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Inter-lab diff for lot B-0114: 96.8% vs 98.1%. Within expected range.
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GIP plus GLP-1
changed my mind about needing 15, i was chasing a number rather than an outcome
15 is the top
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genuine question did anyone go past 15 and was there any point to it
went back to semaglutide after 23 months because the cost difference mattered more than the GI
there is no clean conversion between the two, anyone giving you a ratio is guessing
folklore probably
restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists
did anyone find the GI easier than semaglutide at an equivalent effect
while im here why does everyone talk about 7.5 and not 10
[edited]i went to 15 and came back to 10, more suppression wasnt more useful for me
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
the switch felt like a step down at first and then caught up around week 23
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no clean conversion
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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my VendorInvestigate result on a ERP vial came in at 96.8 which is why i keep buying from them
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plateaued at 7 weeks the same way i did on semaglutide, so i doubt its compound specific, not advice obviously
titrate slow
[edited]the 30 vial in 2ml gives 10mg/ml which puts 12 on 40 units, nice round numbers, someone check my working
40 units of a 10 solution is a lot of volume and i check that one twice every single time
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
at 15 the GI came back for me, so my easier profile claim only applies below that
*VendorInvestigate not the other one
the trials titrated every four weeks to a target, most people here stop at whatever works, n of 1 obviously
im at 12 and thinking about 0.5, did anyone gain anything from that step
SURMOUNT is weight
if youre coming off semaglutide the honest answer is start low and find out, theres no table
went back to semaglutide after 25 months because the cost difference mattered more than the GI
€94 for a 15 vial is roughly what ive paid for the last year
Inter-lab diff for lot E-2205: 96.8% vs 99.2%. Within expected range.
is there a reason to titrate slower than the four week schedule
the two compounds arent interchangeable week for week even if the effect ends up similar, thats just me
coming back to this the GI difference held for me right up to 15, which isnt what a couple of people here found
easier gi for me
i went to 15 and came back to 10, more suppression wasnt more useful for me
at 15 my appetite went completely and i dropped back a step, eating nothing isnt a win
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held 10 for 7 months and lost 15kg over that stretch, slow and boring and fine
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no gap when i switched, took the last semaglutide dose and started this a week later, ymmv
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New independent result logged — GGPeps, lot B-0329, purity 99% (Janoshik).