how did people handle the 2.5 to 5 jump
#tirzepatide 2026-01-15
Thursday16 messages3 participantstimes are UTC
Highlights from this day
- lipase_lore — the switch felt like a step down at first and then caught up around week 7 18:36
- lipase_lore — no gap when i switched, took the last semaglutide dose and started this a week later, anyway 18:37
- rae_labels — why does everyone talk about 7.5 and not 10 18:38
- rae_labels — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 18:47
- lipase_lore — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, still working it out 19:44
the sweet spot argument is really about effect per side effect, not a magic number
SURMOUNT is weight
the switch felt like a step down at first and then caught up around week 7
🎉12
no gap when i switched, took the last semaglutide dose and started this a week later, anyway
why does everyone talk about 7.5 and not 10
transit-times.csv
373 rows · not retained in the public archive
start low anyway
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
titrate slow
🤝7📈15🙏1
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, still working it out
i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
the two compounds arent interchangeable week for week even if the effect ends up similar
no clean conversion
🤝10⚠️1
is the sweet spot argument about effect or about side effects
ok so dual agonist, GIP as well as GLP-1, thats the whole difference in one line