15 is the top
#tirzepatide 2025-11-10
Monday19 messages4 participantstimes are UTC
Highlights from this day
- yyz_vial — i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from 06:00
- apob_over_ldl — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 08:22
- apob_over_ldl — slightly off topic but i log everything and my appetite curve looks flatter across the week than my semaglutide log did GI was noticeably easier for me than… 08:52
does the GIP arm actually explain the easier nausea or is that hand waving
at 15 the GI came back for me, so my easier profile claim only applies below that, we shall see
switched last year
is SURMOUNT-OSA the sleep apnoea one
there is no clean conversion between the two, anyone giving you a ratio is guessing
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i sat at 7.5 for 6 months and never needed more, which is where the folklore comes from
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is there a reason to titrate slower than the four week schedule
folklore probably
[edited]did anybody switch back to semaglutide after trying this
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
coming back to this dual agonist, GIP as well as GLP-1, thats the whole difference in one line
the two compounds arent interchangeable week for week even if the effect ends up similar
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
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did anyone find the GI easier than semaglutide at an equivalent effect
10 was enough
slightly off topic but i log everything and my appetite curve looks flatter across the week than my semaglutide log did
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
titrate slow
is 7.5 really the sweet spot or is that just channel folklore