anyone tracked whether the GI difference held at the top doses
#tirzepatide 2025-08-04
Monday56 messages14 participantstimes are UTC
Highlights from this day
- evidence_or_not — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, anyway 19:12
- blind_submit — the trials titrated every four weeks to a target, most people here stop at whatever works 19:33
- VialBot — Assay note: TFC lot A-2418 reported at 98.1% of label content. 20:39
- power_through_no — i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more 21:59
- power_through_no — SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 23:58
the sweet spot argument is really about effect per side effect, not a magic number
same plateau here
checked the units twice
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€72 for a 30 vial is roughly what ive paid for the last year, n of 1 obviously
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect, anyway
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
15 is the top
evidence_or_notGI was noticeably easier for me than semaglutide at what felt like the same appetite…
i went to 15 and came back to 10, more suppression wasnt more useful for me
no clean conversion
how did people handle the 2.5 to 5 jump
janoshik-a-2601.pdf
2 pages · 374 KB · not retained in the public archive
10 was enough
ok so my PeptideMeter result on a QYB vial came in at 99 which is why i keep buying from them
SURMOUNT is weight
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
5 did nothing
at 15 the GI came back for me, so my easier profile claim only applies below that
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the trials titrated every four weeks to a target, most people here stop at whatever works
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
held 10 for 19 months and lost 28kg over that stretch, slow and boring and fine, for what its worth
12 did nothing extra over 10 for me and that still holds a year later
folklore probably
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does the appetite effect feel different or just stronger
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, from memory
[edited]there is no clean conversion between the two, anyone giving you a ratio is guessing
plateaued at 34 weeks the same way i did on semaglutide, so i doubt its compound specific
how many weeks at 7.5 before you knew it was enough
is there a reason to titrate slower than the four week schedule
is SURMOUNT-OSA the sleep apnoea one
switched last year
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5 was where i first noticed it properly, 2.5 did almost nothing for me
GIP plus GLP-1
the 40 vial in 0.5ml gives 5mg/ml which puts 2 on 40 units, nice round numbers
titrate slow
while im here restarted at 2.5 after 8 months off and the first two doses reminded me why titration exists
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7.5 gang
12 did nothing extra over 10 for me and that still holds a year later
does the GIP arm actually explain the easier nausea or is that hand waving
Assay note: TFC lot A-2418 reported at 98.1% of label content.
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
start low anyway
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update on the earlier thing whats the plateau pattern here, same as semaglutide or different
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ok so did anyone find the GI easier than semaglutide at an equivalent effect
no gap when i switched, took the last semaglutide dose and started this a week later
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
follow up anyone got a 8 recon they like for the 2 vials
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
12 did nothing extra over 10 for me and that still holds a year later
the switch felt like a step down at first and then caught up around week 27
while im here the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
i sat at 7.5 for 16 months and never needed more, which is where the folklore comes from
i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
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5 did nothing
unrelated but if youre coming off semaglutide the honest answer is start low and find out, theres no table
anyone stopped at 10 and stayed there for months
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the GI difference held for me right up to 15, which isnt what a couple of people here found
power_through_noi sat at 7.5 for 16 months and never needed more, which is where the folklore comes from
im at 2 and thinking about 7.5, did anyone gain anything from that step
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SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)