the two compounds arent interchangeable week for week even if the effect ends up similar
#tirzepatide 2026-03-09
Monday31 messages9 participantstimes are UTC
Highlights from this day
- motivation_gone — the 2.5 to 5 step was the roughest one for me and everything after was easier 22:09
- VialBot — Assay note: HJ lot B-0114 reported at 99.4% of label content. 22:26
- motivation_gone — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 23:02
- two_eight_c — i sat at 7.5 for 16 months and never needed more, which is where the folklore comes from 23:34
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
did anybody switch back to semaglutide after trying this
🎉5😂1
at 15 the GI came back for me, so my easier profile claim only applies below that
titrate slow
is SURMOUNT-OSA the sleep apnoea one
is 7.5 really the sweet spot or is that just channel folklore
the switch felt like a step down at first and then caught up around week 16
how long before the dual thing was noticeable to you
checked the units twice
the 2.5 to 5 step was the roughest one for me and everything after was easier
✅1🎉8👀2
the trials titrated every four weeks to a target, most people here stop at whatever works
12 did nothing extra over 10 for me and that still holds a year later
SURMOUNT is weight
Assay note: HJ lot B-0114 reported at 99.4% of label content.
is the sweet spot argument about effect or about side effects
plateaued at 11 weeks the same way i did on semaglutide, so i doubt its compound specific
i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more
if youre coming off semaglutide the honest answer is start low and find out, theres no table
GIP plus GLP-1
£38 for a 20 vial is roughly what ive paid for the last year
5 did nothing
the sweet spot thing is survivorship, the people it worked for stayed and said so
held 10 for 19 months and lost 46kg over that stretch, slow and boring and fine, from memory
the 2.5 to 5 step was the roughest one for me and everything after was easier
folklore probably
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
❤️1🤝14
unrelated but how did people handle the 2.5 to 5 jump
easier gi for me
is the 20 vial the common one or do people use 5
the sweet spot argument is really about effect per side effect, not a magic number
i sat at 7.5 for 16 months and never needed more, which is where the folklore comes from
🧪8✅3🤝4