switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it
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#tirzepatide 2026-01-26
Monday37 messages9 participantstimes are UTC
Highlights from this day
- warsaw_vial — switched from 0.5 semaglutide and started at 2.5, took the slow route, never regretted it 12:59
- slow.taper — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 15:36
- vialkeeper — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 16:09
- vialkeeper — SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up 16:35
i went to 15 and came back to 10, more suppression wasnt more useful for me
no gap when i switched, took the last semaglutide dose and started this a week later
the trials titrated every four weeks to a target, most people here stop at whatever works
Reminder set. I will post here in 7 days.
follow up if youre coming off semaglutide the honest answer is start low and find out, theres no table
i argued the sweet spot was nonsense and then spent 13 months at 7.5 not needing more
5 did nothing
ok so i sat at 7.5 for 18 months and never needed more, which is where the folklore comes from
GIP plus GLP-1
40 units of a 5 solution is a lot of volume and i check that one twice every single time
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no clean conversion
12 did nothing extra over 10 for me and that still holds a year later
for the archive the sweet spot argument is really about effect per side effect, not a magic number
changed my mind about needing 15, i was chasing a number rather than an outcome
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*Medutest not the other one
SURMOUNT is weight
quick one the GI difference held for me right up to 15, which isnt what a couple of people here found
right so how did people handle the 2.5 to 5 jump
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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10 was enough
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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anyone tracked whether the GI difference held at the top doses
the sweet spot thing is survivorship, the people it worked for stayed and said so, someone check my working
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
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whats the top licensed dose, 15 or does it go higher
5 was where i first noticed it properly, 2.5 did almost nothing for me
how long before the dual thing was noticeable to you
checked the units twice
is 7.5 really the sweet spot or is that just channel folklore
the 2 vial in 2.5ml gives 8mg/ml which puts 0.25 on 50 units, nice round numbers
there is no clean conversion between the two, anyone giving you a ratio is guessing
*Janoshik not the other one
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
for the archive restarted at 2.5 after 9 months off and the first two doses reminded me why titration exists
*Medutest not the other one