same plateau here
#tirzepatide 2026-03-18
Wednesday57 messages11 participantstimes are UTC
Highlights from this day
anyone tracked whether the GI difference held at the top doses
SURMOUNT is weight
held 10 for 17 months and lost 4kg over that stretch, slow and boring and fine
Assay note: Homopeptide lot A-2601 reported at 98.6% of label content.
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the 2.5 to 5 step was the roughest one for me and everything after was easier
folklore probably
restarted at 2.5 after 15 months off and the first two doses reminded me why titration exists
switched last year
no clean conversion
at 5 my appetite is gone entirely, did anyone go down rather than up
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easier gi for me
my PeptideMeter result on a Homopeptide vial came in at 98.6 which is why i keep buying from them
the trials titrated every four weeks to a target, most people here stop at whatever works, happy to be corrected
weights-monthly.csv
435 rows · not retained in the public archive
update on the earlier thing plateaued at 6 weeks the same way i did on semaglutide, so i doubt its compound specific
the sweet spot thing is survivorship, the people it worked for stayed and said so
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did anyone go past 15 and was there any point to it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
why does everyone talk about 7.5 and not 10
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changed my mind about needing 15, i was chasing a number rather than an outcome
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licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does, n of 1 obviously
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
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$38 for a 20 vial is roughly what ive paid for the last year
*Janoshik not the other one
went back to semaglutide after 22 months because the cost difference mattered more than the GI
there is no clean conversion between the two, anyone giving you a ratio is guessing
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titrate slow
Recon calculator: 15mg in 1ml = 10mg/ml.
checked the units twice
12 did nothing extra over 10 for me and that still holds a year later
i sat at 7.5 for 21 months and never needed more, which is where the folklore comes from
did anybody switch back to semaglutide after trying this
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update on the earlier thing 40 units of a 10 solution is a lot of volume and i check that one twice every single time
New independent result logged — SWB, lot C-4402, purity 99.2% (PeptideMeter).
quick one the 2 vial in 3ml gives 2.5mg/ml which puts 2.5 on 12 units, nice round numbers
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the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
restarted at 2.5 after 5 months off and the first two doses reminded me why titration exists
at 15 the GI came back for me, so my easier profile claim only applies below that
*VendorInvestigate not the other one
ok so the switch felt like a step down at first and then caught up around week 2
anyone stopped at 10 and stayed there for months
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
quick one SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, i could be wrong
whats the plateau pattern here, same as semaglutide or different
quick one at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
5 was where i first noticed it properly, 2.5 did almost nothing for me
weights-monthly.csv
565 rows · not retained in the public archive
does switching from semaglutide need a gap or do you just start
restarted at 2.5 after 17 months off and the first two doses reminded me why titration exists
*PeptideMeter not the other one
does the GIP arm actually explain the easier nausea or is that hand waving
is 7.5 really the sweet spot or is that just channel folklore
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i went to 15 and came back to 10, more suppression wasnt more useful for me
the two compounds arent interchangeable week for week even if the effect ends up similar, i have it written down somewhere
start low anyway
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no gap when i switched, took the last semaglutide dose and started this a week later
7.5 gang
the GI difference held for me right up to 15, which isnt what a couple of people here found
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anyone got a 5 recon they like for the 5 vials
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
i log everything and my appetite curve looks flatter across the week than my semaglutide log did, i could be wrong
how long before the dual thing was noticeable to you