restarted at 2.5 after 25 months off and the first two doses reminded me why titration exists
#tirzepatide 2026-03-19
Thursday67 messages14 participantstimes are UTC
Highlights from this day
- meniscus_mel — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 19:39
- meniscus_mel — at 0.25 my appetite is gone entirely, did anyone go down rather than up 19:56
- VialBot — Assay note: WWB lot B-0329 reported at 98.6% of label content. 20:51
- cold_chain_cmdr — slightly off topic but i log everything and my appetite curve looks flatter across the week than my semaglutide log did 22:27
how did people handle the 2.5 to 5 jump
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)did anybody switch back to semaglutide after trying this
does switching from semaglutide need a gap or do you just start
the two compounds arent interchangeable week for week even if the effect ends up similar
at 15 the GI came back for me, so my easier profile claim only applies below that
coa-h-2814.pdf
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the sweet spot thing is survivorship, the people it worked for stayed and said so
at 0.25 my appetite is gone entirely, did anyone go down rather than up
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no clean conversion
15 is the top
*Janoshik not the other one
changed my mind about needing 15, i was chasing a number rather than an outcome
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switched from 12 semaglutide and started at 2.5, took the slow route, never regretted it
back after 5 months, do i restart at 2.5 or pick up near where i left off
my VendorInvestigate result on a ERP vial came in at 99.4 which is why i keep buying from them
is the sweet spot argument about effect or about side effects
[edited]the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, happy to be corrected
why does everyone talk about 7.5 and not 10
is there a reason to titrate slower than the four week schedule
[edited]is the 5 vial the common one or do people use 20
does the GIP arm actually explain the easier nausea or is that hand waving
the trials titrated every four weeks to a target, most people here stop at whatever works
the switch felt like a step down at first and then caught up around week 2
5 was where i first noticed it properly, 2.5 did almost nothing for me
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did anyone go past 15 and was there any point to it
coming off semaglutide, is there a conversion or do i restart at 2.5
i argued the sweet spot was nonsense and then spent 14 months at 7.5 not needing more
Assay note: WWB lot B-0329 reported at 98.6% of label content.
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did going from 1.7 semaglutide to 5 of this feel like a step down for anyone
same plateau here
is 7.5 really the sweet spot or is that just channel folklore
[edited]does the appetite effect feel different or just stronger
sorry to jump in 40 units of a 4 solution is a lot of volume and i check that one twice every single time
start low anyway
the 20 vial in 5ml gives 2.5mg/ml which puts 0.5 on 30 units, nice round numbers
no gap when i switched, took the last semaglutide dose and started this a week later
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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there is no clean conversion between the two, anyone giving you a ratio is guessing
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went back to semaglutide after 13 months because the cost difference mattered more than the GI
checked the units twice
is SURMOUNT-OSA the sleep apnoea one
SURMOUNT is weight
titrate slow
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
easier gi for me
5 did nothing
did anyone find the GI easier than semaglutide at an equivalent effect
[edited]folklore probably
anyone stopped at 10 and stayed there for months
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GIP plus GLP-1
quick one GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
i argued the sweet spot was nonsense and then spent 26 months at 7.5 not needing more
for the archive dual agonist, GIP as well as GLP-1, thats the whole difference in one line
i went to 15 and came back to 10, more suppression wasnt more useful for me
if youre coming off semaglutide the honest answer is start low and find out, theres no table
[edited]10 was enough
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
dana_titratesSURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix…
slightly off topic but i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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7.5 gang
plateaued at 6 weeks the same way i did on semaglutide, so i doubt its compound specific
the 2.5 to 5 step was the roughest one for me and everything after was easier
SURMOUNT is weight
my Janoshik result on a WWB vial came in at 99 which is why i keep buying from them
held 10 for 22 months and lost 17kg over that stretch, slow and boring and fine
switched last year
anyone got a 5 recon they like for the 10 vials
how many weeks at 7.5 before you knew it was enough
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the sweet spot argument is really about effect per side effect, not a magic number