#tirzepatide 2025-12-15

Monday22 messages5 participantstimes are UTC

Highlights from this day

amylin_amy — at 15 the GI came back for me, so my easier profile claim only applies below that 05:30
comment_fatigue — i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more 06:39
mag_citrate — i log everything and my appetite curve looks flatter across the week than my semaglutide log did no gap when i switched, took the last semaglutide dose and started… 07:03
meniscus_mel — there is no clean conversion between the two, anyone giving you a ratio is guessing, anyway 07:40

amylin_amy 05:25

10 was enough

switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it

📈2🎉1

at 15 the GI came back for me, so my easier profile claim only applies below that

✅11💀4

at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win

🧊9

comment_fatigue 05:32

is SURMOUNT-OSA the sleep apnoea one

comment_fatigue 06:37

same plateau here

i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

if youre coming off semaglutide the honest answer is start low and find out, theres no table

ms_ms_miralab06:44

7.5 gang

🤝2👀3🎉2

the sweet spot thing is survivorship, the people it worked for stayed and said so

whats the top licensed dose, 15 or does it go higher

amylin_amy switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it

ms_ms_miralab06:57

sorry to jump in licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does

GIP plus GLP-1

is 7.5 really the sweet spot or is that just channel folklore

comment_fatigue if youre coming off semaglutide the honest answer is start low and find out, theres no…

meniscus_mel 07:01

did anybody switch back to semaglutide after trying this

mag_citrate 07:03

i log everything and my appetite curve looks flatter across the week than my semaglutide log did
no gap when i switched, took the last semaglutide dose and started this a week later

[edited]

Cited study

Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)

New England Journal of Medicine · 2024

AHI as the primary endpoint, with and without PAP therapy.

restarted at 2.5 after 22 months off and the first two doses reminded me why titration exists, thats one data point

*that should say weekly

comment_fatigue 07:07

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

meniscus_mel 07:40

there is no clean conversion between the two, anyone giving you a ratio is guessing, anyway

📈13✅2

meniscus_mel 08:20

5 did nothing

comment_fatigue 08:21

the GI difference held for me right up to 15, which isnt what a couple of people here found