update on the earlier thing how long before the dual thing was noticeable to you
#tirzepatide 2025-07-20
Sunday64 messages11 participantstimes are UTC
Highlights from this day
- noct.titrate — changed my mind about needing 15, i was chasing a number rather than an outcome, i think held 10 for 13 months and lost 32kg over that stretch, slow and boring and fine 18:49
- noct.titrate — right so no gap when i switched, took the last semaglutide dose and started this a week later licensed top is 15 weekly, past that is not a licensed dose and nobody… 18:51
- deamidation — the switch felt like a step down at first and then caught up around week 26 19:21
- deamidation — coming back to this back after 15 months, do i restart at 2.5 or pick up near where i left off 22:37
did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
quick one anyone tracked whether the GI difference held at the top doses
changed my mind about needing 15, i was chasing a number rather than an outcome, i think
held 10 for 13 months and lost 32kg over that stretch, slow and boring and fine
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right so no gap when i switched, took the last semaglutide dose and started this a week later
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
fridge-temps.csv
840 rows · not retained in the public archive
plateaued at 3 weeks the same way i did on semaglutide, so i doubt its compound specific
12 did nothing extra over 10 for me and that still holds a year later
how did people handle the 2.5 to 5 jump
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
anyone got a 4 recon they like for the 20 vials
*Medutest not the other one
10 was enough
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start low anyway
the switch felt like a step down at first and then caught up around week 26
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
easier gi for me
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there is no clean conversion between the two, anyone giving you a ratio is guessing
the trials titrated every four weeks to a target, most people here stop at whatever works
19:40marrow.mod pinned a message to this channel
the sweet spot argument is really about effect per side effect, not a magic number
i argued the sweet spot was nonsense and then spent 23 months at 7.5 not needing more
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
titrate slow
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went back to semaglutide after 7 months because the cost difference mattered more than the GI
40 units of a 8 solution is a lot of volume and i check that one twice every single time
transit-times.csv
633 rows · not retained in the public archive
is there a reason to titrate slower than the four week schedule
sorry to jump in did anyone go past 15 and was there any point to it
12 did nothing extra over 10 for me and that still holds a year later
my PeptideMeter result on a JEEP vial came in at 99 which is why i keep buying from them
SURMOUNT is weight
does the appetite effect feel different or just stronger
[edited]switched last year
did anyone find the GI easier than semaglutide at an equivalent effect
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dual agonist, GIP as well as GLP-1, thats the whole difference in one line
5 did nothing
the two compounds arent interchangeable week for week even if the effect ends up similar
right so does the GIP arm actually explain the easier nausea or is that hand waving
5 was where i first noticed it properly, 2.5 did almost nothing for me, we shall see
how many weeks at 7.5 before you knew it was enough
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
GIP plus GLP-1
folklore probably
ok so restarted at 2.5 after 17 months off and the first two doses reminded me why titration exists
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reta_resting_hrhow many weeks at 7.5 before you knew it was enough at 2.4 my appetite went completely…
i went to 15 and came back to 10, more suppression wasnt more useful for me
the sweet spot thing is survivorship, the people it worked for stayed and said so, from memory
reta_resting_hrhow many weeks at 7.5 before you knew it was enough at 2.4 my appetite went completely…
£38 for a 30 vial is roughly what ive paid for the last year
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
7.5 gang
if youre coming off semaglutide the honest answer is start low and find out, theres no table, thats one data point
i sat at 7.5 for 14 months and never needed more, which is where the folklore comes from
right so 15 is the top
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
held 10 for 14 months and lost 42kg over that stretch, slow and boring and fine
*that should say weekly
anyone stopped at 10 and stayed there for months
ok so does switching from semaglutide need a gap or do you just start
the 15 vial in 2ml gives 4mg/ml which puts 1 on 50 units, nice round numbers, thats just me
at 2.4 my appetite went completely and i dropped back a step, eating nothing isnt a win
is 7.5 really the sweet spot or is that just channel folklore
whats the top licensed dose, 15 or does it go higher
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folklore probably
im at 7.5 and thinking about 2.4, did anyone gain anything from that step
coming back to this back after 15 months, do i restart at 2.5 or pick up near where i left off
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at 1 my appetite is gone entirely, did anyone go down rather than up
did anybody switch back to semaglutide after trying this
[edited]