if youre coming off semaglutide the honest answer is start low and find out, theres no table
#tirzepatide 2026-05-07
Thursday55 messages11 participantstimes are UTC
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does the appetite effect feel different or just stronger
the 2.5 to 5 step was the roughest one for me and everything after was easier
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$120 for a 5 vial is roughly what ive paid for the last year, thats one data point
plateaued at 2 weeks the same way i did on semaglutide, so i doubt its compound specific
for the archive anyone got a 8 recon they like for the 10 vials
is SURMOUNT-OSA the sleep apnoea one
checked the units twice
same plateau here
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, take that with a pinch of salt
the switch felt like a step down at first and then caught up around week 17
quick one the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
40 units of a 2 solution is a lot of volume and i check that one twice every single time
the trials titrated every four weeks to a target, most people here stop at whatever works
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
the two compounds arent interchangeable week for week even if the effect ends up similar, still working it out
switched last year
sorry to jump in at 15 the GI came back for me, so my easier profile claim only applies below that
folklore probably
GIP plus GLP-1
follow up i argued the sweet spot was nonsense and then spent 3 months at 7.5 not needing more
went back to semaglutide after 1 months because the cost difference mattered more than the GI
the two compounds arent interchangeable week for week even if the effect ends up similar
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
did anybody switch back to semaglutide after trying this
start low anyway
ok so whats the plateau pattern here, same as semaglutide or different
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
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15 is the top
how long before the dual thing was noticeable to you
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my VendorInvestigate result on a QYB vial came in at 96.8 which is why i keep buying from them
5 was where i first noticed it properly, 2.5 did almost nothing for me
at 7.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
for the archive did anyone find the GI easier than semaglutide at an equivalent effect
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quick one GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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restarted at 2.5 after 15 months off and the first two doses reminded me why titration exists
the sweet spot argument is really about effect per side effect, not a magic number
SURMOUNT is weight
7.5 gang
i went to 15 and came back to 10, more suppression wasnt more useful for me, we shall see
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
12 did nothing extra over 10 for me and that still holds a year later
held 10 for 16 months and lost 29kg over that stretch, slow and boring and fine
did going from 15 semaglutide to 5 of this feel like a step down for anyone
easier gi for me
for the archive 7.5 gang
did anyone go past 15 and was there any point to it
[edited]titrate slow
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does the GIP arm actually explain the easier nausea or is that hand waving
no clean conversion
5 did nothing
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
coming off semaglutide, is there a conversion or do i restart at 2.5
[edited]the 10 vial in 2ml gives 10mg/ml which puts 12 on 40 units, nice round numbers
*mg/ml, obviously
there is no clean conversion between the two, anyone giving you a ratio is guessing
changed my mind about needing 15, i was chasing a number rather than an outcome