quick one changed my mind about needing 15, i was chasing a number rather than an outcome, i think
#tirzepatide 2026-04-13
Monday26 messages6 participantstimes are UTC
Highlights from this day
- apob_over_ldl — there is no clean conversion between the two, anyone giving you a ratio is guessing 14:47
- gip_glp_gil — coming off semaglutide, is there a conversion or do i restart at 2.5 16:34
- apob_over_ldl — the switch felt like a step down at first and then caught up around week 29 18:02
- orfor_watch — the 5 vial in 0.5ml gives 10mg/ml which puts 0.5 on 50 units, nice round numbers held 10 for 1 months and lost 37kg over that stretch, slow and boring and fine 18:04
- orfor_watch — did going from 0.5 semaglutide to 5 of this feel like a step down for anyone SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted 18:14
anyone got a 10 recon they like for the 40 vials
the two compounds arent interchangeable week for week even if the effect ends up similar
*week 11 not week 8
the trials titrated every four weeks to a target, most people here stop at whatever works
7.5 gang
😂3❤️6
15 is the top
no clean conversion
there is no clean conversion between the two, anyone giving you a ratio is guessing
😂2❤️4
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
is the sweet spot argument about effect or about side effects
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
checked the units twice
ok so is there a reason to titrate slower than the four week schedule
at 2.4 my appetite is gone entirely, did anyone go down rather than up
[edited]coming off semaglutide, is there a conversion or do i restart at 2.5
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)did anyone find the GI easier than semaglutide at an equivalent effect
the GI difference held for me right up to 15, which isnt what a couple of people here found
SURMOUNT is weight
5 did nothing
the sweet spot thing is survivorship, the people it worked for stayed and said so
👀1
40 units of a 5 solution is a lot of volume and i check that one twice every single time
the switch felt like a step down at first and then caught up around week 29
💀3📈7🧊4
the 5 vial in 0.5ml gives 10mg/ml which puts 0.5 on 50 units, nice round numbers
held 10 for 1 months and lost 37kg over that stretch, slow and boring and fine
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
€120 for a 10 vial is roughly what ive paid for the last year
did going from 0.5 semaglutide to 5 of this feel like a step down for anyone
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted