the trials titrated every four weeks to a target, most people here stop at whatever works
#tirzepatide 2026-03-14
Saturday17 messages6 participantstimes are UTC
Highlights from this day
- u100_pat — if youre coming off semaglutide the honest answer is start low and find out, theres no table at 1.7 my appetite went completely and i dropped back a step, eating… 17:28
- willow_waits — the sweet spot argument is really about effect per side effect, not a magic number 17:59
- seven_five_sweet — is SURMOUNT-OSA the sleep apnoea one 19:49
- seven_five_sweet — i went to 15 and came back to 10, more suppression wasnt more useful for me the GI difference held for me right up to 15, which isnt what a couple of people here found 20:05
if youre coming off semaglutide the honest answer is start low and find out, theres no table
at 1.7 my appetite went completely and i dropped back a step, eating nothing isnt a win
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)same plateau here
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
did anyone go past 15 and was there any point to it
there is no clean conversion between the two, anyone giving you a ratio is guessing
the sweet spot argument is really about effect per side effect, not a magic number
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SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, take that with a pinch of salt
£240 for a 5 vial is roughly what ive paid for the last year
back after 24 months, do i restart at 2.5 or pick up near where i left off
how many weeks at 7.5 before you knew it was enough
anyone stopped at 10 and stayed there for months
is SURMOUNT-OSA the sleep apnoea one
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the two compounds arent interchangeable week for week even if the effect ends up similar
the 2 vial in 2.5ml gives 8mg/ml which puts 1.7 on 8 units, nice round numbers
i went to 15 and came back to 10, more suppression wasnt more useful for me
the GI difference held for me right up to 15, which isnt what a couple of people here found
the 2.5 to 5 step was the roughest one for me and everything after was easier