$185 for a 10 vial is roughly what ive paid for the last year
#tirzepatide 2026-01-31
Saturday62 messages12 participantstimes are UTC
Highlights from this day
- tail_factor — i log everything and my appetite curve looks flatter across the week than my semaglutide log did 16:13
- ferrous_ash — at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win 17:12
- ferrous_ash — held 10 for 26 months and lost 47kg over that stretch, slow and boring and fine, your mileage will differ 17:33
- ferrous_ash — switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it 17:37
*VendorInvestigate not the other one
did anybody switch back to semaglutide after trying this
folklore probably
i argued the sweet spot was nonsense and then spent 6 months at 7.5 not needing more
start low anyway
14:08ferrous_ash pinned a message to this channel
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no gap when i switched, took the last semaglutide dose and started this a week later
15 is the top
10 was enough
anyone stopped at 10 and stayed there for months
back after 19 months, do i restart at 2.5 or pick up near where i left off
14:44ferrous_ash pinned a message
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
how did people handle the 2.5 to 5 jump
Recon calculator: 15mg in 3ml = 8mg/ml.
anyone tracked whether the GI difference held at the top doses
titrate slow
5 did nothing
coming back to this plateaued at 19 weeks the same way i did on semaglutide, so i doubt its compound specific
there is no clean conversion between the two, anyone giving you a ratio is guessing
the trials titrated every four weeks to a target, most people here stop at whatever works
my PeptideMeter result on a JEEP vial came in at 99.4 which is why i keep buying from them
7.5 gang
same plateau here
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SURMOUNT is weight
at 15 the GI came back for me, so my easier profile claim only applies below that, i could be wrong
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up, thats one data point
the switch felt like a step down at first and then caught up around week 10, thats just me
[edited]whats the plateau pattern here, same as semaglutide or different
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
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the two compounds arent interchangeable week for week even if the effect ends up similar, not advice obviously
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no clean conversion
easier gi for me
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did going from 12 semaglutide to 5 of this feel like a step down for anyone
dual agonist, GIP as well as GLP-1, thats the whole difference in one line, someone check my working
checked the units twice
Batch lookup H-2814: 4 independent reports on file, earliest 2025-03-11.
is the 15 vial the common one or do people use 10
is SURMOUNT-OSA the sleep apnoea one
at 10 my appetite went completely and i dropped back a step, eating nothing isnt a win
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held 10 for 26 months and lost 47kg over that stretch, slow and boring and fine, your mileage will differ
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40 units of a 2 solution is a lot of volume and i check that one twice every single time
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
if youre coming off semaglutide the honest answer is start low and find out, theres no table
the 5 vial in 3ml gives 5mg/ml which puts 5 on 10 units, nice round numbers
at 15 the GI came back for me, so my easier profile claim only applies below that
for the archive is the sweet spot argument about effect or about side effects
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
the 2.5 to 5 step was the roughest one for me and everything after was easier
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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switched last year
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how many weeks at 7.5 before you knew it was enough
the sweet spot argument is really about effect per side effect, not a magic number
i sat at 7.5 for 3 months and never needed more, which is where the folklore comes from
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
5 was where i first noticed it properly, 2.5 did almost nothing for me
coming back to this why does everyone talk about 7.5 and not 10
for the archive did anyone find the GI easier than semaglutide at an equivalent effect
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
the GI difference held for me right up to 15, which isnt what a couple of people here found
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restarted at 2.5 after 2 months off and the first two doses reminded me why titration exists, thats just me
changed my mind about needing 15, i was chasing a number rather than an outcome