15 is the top
#tirzepatide 2025-12-17
Wednesday60 messages11 participantstimes are UTC
Highlights from this day
- sol_sends — the sweet spot thing is survivorship, the people it worked for stayed and said so licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell… 16:17
- sol_sends — switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it 16:24
- third_shift — my Janoshik result on a GGPeps vial came in at 97.4 which is why i keep buying from them, ask me again in a month 17:23
- third_shift — while im here does the GIP arm actually explain the easier nausea or is that hand waving 17:26
- cross_border_cam — the sweet spot argument is really about effect per side effect, not a magic number, happy to be corrected 17:30
the sweet spot thing is survivorship, the people it worked for stayed and said so
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)10 was enough
switched from 0.25 semaglutide and started at 2.5, took the slow route, never regretted it
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did anyone go past 15 and was there any point to it
while im here anyone tracked whether the GI difference held at the top doses
at 15 my appetite went completely and i dropped back a step, eating nothing isnt a win
i argued the sweet spot was nonsense and then spent 26 months at 7.5 not needing more, ask me again in a month
SURMOUNT is weight
restarted at 2.5 after 8 months off and the first two doses reminded me why titration exists
is there a reason to titrate slower than the four week schedule
folklore probably
ok so is the 30 vial the common one or do people use 15
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
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genuine question plateaued at 32 weeks the same way i did on semaglutide, so i doubt its compound specific
sorry to jump in changed my mind about needing 15, i was chasing a number rather than an outcome
whats the top licensed dose, 15 or does it go higher
my Janoshik result on a GGPeps vial came in at 97.4 which is why i keep buying from them, ask me again in a month
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while im here does the GIP arm actually explain the easier nausea or is that hand waving
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held 10 for 11 months and lost 7kg over that stretch, slow and boring and fine
the sweet spot argument is really about effect per side effect, not a magic number, happy to be corrected
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the 2.5 to 5 step was the roughest one for me and everything after was easier
i sat at 7.5 for 1 months and never needed more, which is where the folklore comes from
is SURMOUNT-OSA the sleep apnoea one
why does everyone talk about 7.5 and not 10
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checked the units twice
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5 did nothing
anyone stopped at 10 and stayed there for months
how many weeks at 7.5 before you knew it was enough
how long before the dual thing was noticeable to you
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
coming off semaglutide, is there a conversion or do i restart at 2.5
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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back after 22 months, do i restart at 2.5 or pick up near where i left off
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the two compounds arent interchangeable week for week even if the effect ends up similar
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at 0.25 my appetite is gone entirely, did anyone go down rather than up
12 did nothing extra over 10 for me and that still holds a year later
did anybody switch back to semaglutide after trying this
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
no gap when i switched, took the last semaglutide dose and started this a week later
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start low anyway
[edited]switched last year
easier gi for me
the 2 vial in 1.5ml gives 2.5mg/ml which puts 15 on 40 units, nice round numbers
follow up went back to semaglutide after 18 months because the cost difference mattered more than the GI, not advice obviously
at 15 the GI came back for me, so my easier profile claim only applies below that
does switching from semaglutide need a gap or do you just start
did anyone find the GI easier than semaglutide at an equivalent effect
the switch felt like a step down at first and then caught up around week 17
GIP plus GLP-1
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Reminder for surpass_two: dose day is today. Set 6 days ago.
Batch lookup F-1330: 7 independent reports on file, earliest 2025-07-06.
same plateau here
7.5 gang
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)titrate slow
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5 was where i first noticed it properly, 2.5 did almost nothing for me
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follow up whats the plateau pattern here, same as semaglutide or different
does the appetite effect feel different or just stronger
40 units of a 8 solution is a lot of volume and i check that one twice every single time