#tirzepatide 2026-04-25

Saturday21 messages7 participantstimes are UTC

Highlights from this day

mcg_not_mg — how long before the dual thing was noticeable to you i went to 15 and came back to 10, more suppression wasnt more useful for me 22:52
apob_over_ldl — the switch felt like a step down at first and then caught up around week 31 23:13
ivy_injects — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, thats one data point 23:16
step_one_sian — the sweet spot thing is survivorship, the people it worked for stayed and said so 23:22

ok so went back to semaglutide after 22 months because the cost difference mattered more than the GI

the sweet spot argument is really about effect per side effect, not a magic number

update on the earlier thing i log everything and my appetite curve looks flatter across the week than my semaglutide log did

[edited]

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

genuine question coming off semaglutide, is there a conversion or do i restart at 2.5

🧊1

start low anyway

how long before the dual thing was noticeable to you
i went to 15 and came back to 10, more suppression wasnt more useful for me

GI was noticeably easier for me than semaglutide at what felt like the same appetite effect

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted, n of 1 obviously

switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it, for what its worth

5 did nothing

the switch felt like a step down at first and then caught up around week 31

fridge-temps.csv

464 rows · not retained in the public archive

✅5📉4

no gap when i switched, took the last semaglutide dose and started this a week later

the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, thats one data point

✅5

the sweet spot thing is survivorship, the people it worked for stayed and said so

✅1🔥1💀11

the two compounds arent interchangeable week for week even if the effect ends up similar

i argued the sweet spot was nonsense and then spent 24 months at 7.5 not needing more

the GI difference held for me right up to 15, which isnt what a couple of people here found, i think

anyone tracked whether the GI difference held at the top doses

licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does

whats the plateau pattern here, same as semaglutide or different