folklore probably
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)#tirzepatide 2025-11-27
Thursday18 messages3 participantstimes are UTC
Highlights from this day
- plateau_pen — 12 did nothing extra over 10 for me and that still holds a year later 15:39
- apob_over_ldl — plateaued at 26 weeks the same way i did on semaglutide, so i doubt its compound specific 16:09
- apob_over_ldl — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact 16:18
- apob_over_ldl — licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does SURMOUNT was the weight programme and SURPASS was diabetes,… 16:43
- seven_five_sweet — if youre coming off semaglutide the honest answer is start low and find out, theres no table 16:56
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
12 did nothing extra over 10 for me and that still holds a year later
👍8🧊7😂1
plateaued at 26 weeks the same way i did on semaglutide, so i doubt its compound specific
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
is SURMOUNT-OSA the sleep apnoea one
anyone tracked whether the GI difference held at the top doses
checked the units twice
GIP plus GLP-1
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
🎉11😂18
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
🎉7🔥2
10 was enough
how did people handle the 2.5 to 5 jump
whats the plateau pattern here, same as semaglutide or different
if youre coming off semaglutide the honest answer is start low and find out, theres no table
✅2😂13🔥14
at 15 the GI came back for me, so my easier profile claim only applies below that
went back to semaglutide after 18 months because the cost difference mattered more than the GI
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
my Janoshik result on a QSC vial came in at 99 which is why i keep buying from them