SURMOUNT is weight
#tirzepatide 2026-03-04
Wednesday29 messages9 participantstimes are UTC
Highlights from this day
- blind_submit — follow up did anyone find the GI easier than semaglutide at an equivalent effect 09:17
- gradient_greg — the two compounds arent interchangeable week for week even if the effect ends up similar 09:19
- nhs_pathway_nell — does the GIP arm actually explain the easier nausea or is that hand waving 09:21
the trials titrated every four weeks to a target, most people here stop at whatever works
at 15 the GI came back for me, so my easier profile claim only applies below that
40 units of a 8 solution is a lot of volume and i check that one twice every single time
anyone tracked whether the GI difference held at the top doses
07:03quiet.hours pinned a message
the sweet spot thing is survivorship, the people it worked for stayed and said so
i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from
i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more
same plateau here
🔥3🤝2
switched from 2.4 semaglutide and started at 2.5, took the slow route, never regretted it
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
5 did nothing
changed my mind about needing 15, i was chasing a number rather than an outcome
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
is there a reason to titrate slower than the four week schedule
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is the sweet spot argument about effect or about side effects
im at 1 and thinking about 15, did anyone gain anything from that step
no clean conversion
how long before the dual thing was noticeable to you
5 was where i first noticed it properly, 2.5 did almost nothing for me
10 was enough
start low anyway
my Medutest result on a JEEP vial came in at 99 which is why i keep buying from them
follow up did anyone find the GI easier than semaglutide at an equivalent effect
🤝13
comment_fatigue40 units of a 8 solution is a lot of volume and i check that one twice every single time
the two compounds arent interchangeable week for week even if the effect ends up similar
🔥10📈5
i went to 15 and came back to 10, more suppression wasnt more useful for me
does the GIP arm actually explain the easier nausea or is that hand waving