the 2 vial in 2.5ml gives 8mg/ml which puts 7.5 on 50 units, nice round numbers
#tirzepatide 2026-04-29
Wednesday47 messages10 participantstimes are UTC
Highlights from this day
- nettle_notes — no gap when i switched, took the last semaglutide dose and started this a week later 16:36
- juniper_joins — right so plateaued at 2 weeks the same way i did on semaglutide, so i doubt its compound specific, not advice obviously held 10 for 26 months and lost 8kg over that… 16:41
- nettle_notes — how long before the dual thing was noticeable to you licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does 17:12
- juniper_joins — does switching from semaglutide need a gap or do you just start 17:13
- juniper_joins — quick one held 10 for 24 months and lost 47kg over that stretch, slow and boring and fine 17:34
start low anyway
GIP plus GLP-1
switched from 10 semaglutide and started at 2.5, took the slow route, never regretted it
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
coming back to this 40 units of a 5 solution is a lot of volume and i check that one twice every single time
€38 for a 10 vial is roughly what ive paid for the last year
same plateau here
checked the units twice
switched last year
unrelated but does the GIP arm actually explain the easier nausea or is that hand waving
i went to 15 and came back to 10, more suppression wasnt more useful for me
10 was enough
anyone stopped at 10 and stayed there for months
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quick one anyone tracked whether the GI difference held at the top doses
15 is the top
anyone got a 10 recon they like for the 30 vials
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while im here my PeptideMeter result on a HJ vial came in at 99.2 which is why i keep buying from them
i sat at 7.5 for 1 months and never needed more, which is where the folklore comes from
the 2.5 to 5 step was the roughest one for me and everything after was easier, from memory
no gap when i switched, took the last semaglutide dose and started this a week later
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i log everything and my appetite curve looks flatter across the week than my semaglutide log did
right so plateaued at 2 weeks the same way i did on semaglutide, so i doubt its compound specific, not advice obviously
held 10 for 26 months and lost 8kg over that stretch, slow and boring and fine
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the trials titrated every four weeks to a target, most people here stop at whatever works
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
jute_journalsunrelated but does the GIP arm actually explain the easier nausea or is that hand waving
how long before the dual thing was noticeable to you
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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does switching from semaglutide need a gap or do you just start
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restarted at 2.5 after 3 months off and the first two doses reminded me why titration exists
quick one held 10 for 24 months and lost 47kg over that stretch, slow and boring and fine
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went back to semaglutide after 21 months because the cost difference mattered more than the GI
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
7.5 gang
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the GI difference held for me right up to 15, which isnt what a couple of people here found
sorry to jump in 5 was where i first noticed it properly, 2.5 did almost nothing for me
the two compounds arent interchangeable week for week even if the effect ends up similar
Reminder set. I will post here in 3 days.
titrate slow
is the sweet spot argument about effect or about side effects
the switch felt like a step down at first and then caught up around week 15, thats just me
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
did anyone go past 15 and was there any point to it
if youre coming off semaglutide the honest answer is start low and find out, theres no table
ok so at 15 the GI came back for me, so my easier profile claim only applies below that, anyway
12 did nothing extra over 10 for me and that still holds a year later, take that with a pinch of salt
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
the sweet spot argument is really about effect per side effect, not a magic number
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easier gi for me