checked the units twice
Cited study
Tirzepatide for Obstructive Sleep Apnea and Obesity (SURMOUNT-OSA)
New England Journal of Medicine · 2024
AHI as the primary endpoint, with and without PAP therapy.
checked the units twice
#tirzepatide 2026-05-29
Friday53 messages12 participantstimes are UTC
Highlights from this day
- ghent_gradient — the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, for what its worth went back to semaglutide after 1 months because the… 17:56
- ghent_gradient — does switching from semaglutide need a gap or do you just start 18:02
- customs_owl — follow up 40 units of a 2.5 solution is a lot of volume and i check that one twice every single time 18:43
- surpass_two — back after 16 months, do i restart at 2.5 or pick up near where i left off 19:01
- satiety_sig — anyone stopped at 10 and stayed there for months i argued the sweet spot was nonsense and then spent 22 months at 7.5 not needing more 19:40
Channel stats, last 30 days: 130 messages from 22 members.
folklore probably
did anyone find the GI easier than semaglutide at an equivalent effect
quick one anyone got a 8 recon they like for the 20 vials
5 was where i first noticed it properly, 2.5 did almost nothing for me
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
right so did anyone go past 15 and was there any point to it
did anybody switch back to semaglutide after trying this
i sat at 7.5 for 19 months and never needed more, which is where the folklore comes from, happy to be corrected
titrate slow
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact, for what its worth
went back to semaglutide after 1 months because the cost difference mattered more than the GI
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coming back to this how many weeks at 7.5 before you knew it was enough
does switching from semaglutide need a gap or do you just start
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i went to 15 and came back to 10, more suppression wasnt more useful for me
i argued the sweet spot was nonsense and then spent 7 months at 7.5 not needing more
12 did nothing extra over 10 for me and that still holds a year later
no clean conversion
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at 5 my appetite went completely and i dropped back a step, eating nothing isnt a win
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does the GIP arm actually explain the easier nausea or is that hand waving
the sweet spot argument is really about effect per side effect, not a magic number
follow up 40 units of a 2.5 solution is a lot of volume and i check that one twice every single time
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no gap when i switched, took the last semaglutide dose and started this a week later
anyone tracked whether the GI difference held at the top doses
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at 2 my appetite is gone entirely, did anyone go down rather than up
easier gi for me
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back after 16 months, do i restart at 2.5 or pick up near where i left off
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)👍7🤝14😂1
went back to semaglutide after 17 months because the cost difference mattered more than the GI, your mileage will differ
the switch felt like a step down at first and then caught up around week 22
7.5 gang
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coming back to this whats the plateau pattern here, same as semaglutide or different
10 was enough
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
anyone stopped at 10 and stayed there for months
i argued the sweet spot was nonsense and then spent 22 months at 7.5 not needing more
SURMOUNT is weight
same plateau here
did going from 2.4 semaglutide to 5 of this feel like a step down for anyone
the 2.5 to 5 step was the roughest one for me and everything after was easier
the sweet spot thing is survivorship, the people it worked for stayed and said so
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
GIP plus GLP-1
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the two compounds arent interchangeable week for week even if the effect ends up similar
start low anyway
5 did nothing
does the appetite effect feel different or just stronger
held 10 for 18 months and lost 39kg over that stretch, slow and boring and fine, still working it out
how long before the dual thing was noticeable to you
the trials titrated every four weeks to a target, most people here stop at whatever works
same plateau here
changed my mind about needing 15, i was chasing a number rather than an outcome
switched last year
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restarted at 2.5 after 3 months off and the first two doses reminded me why titration exists