40 units of a 10 solution is a lot of volume and i check that one twice every single time
#tirzepatide 2025-08-05
Tuesday50 messages8 participantstimes are UTC
Highlights from this day
- snac_and_water — the trials titrated every four weeks to a target, most people here stop at whatever works 19:59
- pia_plateaus — my PeptideMeter result on a QST vial came in at 98.6 which is why i keep buying from them 20:19
- pia_plateaus — the sweet spot argument is really about effect per side effect, not a magic number the 2.5 to 5 step was the roughest one for me and everything after was easier 20:31
is there a reason to titrate slower than the four week schedule
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more, take that with a pinch of salt
genuine question i went to 15 and came back to 10, more suppression wasnt more useful for me
whats the top licensed dose, 15 or does it go higher
[edited]licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
titrate slow
plateaued at 7 weeks the same way i did on semaglutide, so i doubt its compound specific, happy to be corrected
switched from 2.5 semaglutide and started at 2.5, took the slow route, never regretted it
slightly off topic but if youre coming off semaglutide the honest answer is start low and find out, theres no table
start low anyway
is_this_foreverlicensed top is 15 weekly, past that is not a licensed dose and nobody here can tell…
at 2 my appetite is gone entirely, did anyone go down rather than up
5 did nothing
the two compounds arent interchangeable week for week even if the effect ends up similar, your mileage will differ
went back to semaglutide after 6 months because the cost difference mattered more than the GI, take that with a pinch of salt
whats the plateau pattern here, same as semaglutide or different
slightly off topic but changed my mind about needing 15, i was chasing a number rather than an outcome
did anyone find the GI easier than semaglutide at an equivalent effect
no gap when i switched, took the last semaglutide dose and started this a week later
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did anybody switch back to semaglutide after trying this
the trials titrated every four weeks to a target, most people here stop at whatever works
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)🧊1🎉15
On this day 5 years ago this channel logged 68 messages.
back after 16 months, do i restart at 2.5 or pick up near where i left off
the switch felt like a step down at first and then caught up around week 26
follow up SURMOUNT-1 versus SURPASS-2, which one was the weight trial
my PeptideMeter result on a QST vial came in at 98.6 which is why i keep buying from them
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folklore probably
[edited]how long before the dual thing was noticeable to you
the sweet spot argument is really about effect per side effect, not a magic number
the 2.5 to 5 step was the roughest one for me and everything after was easier
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
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easier gi for me
does switching from semaglutide need a gap or do you just start
how many weeks at 7.5 before you knew it was enough
held 10 for 21 months and lost 20kg over that stretch, slow and boring and fine
does the GIP arm actually explain the easier nausea or is that hand waving
SURMOUNT is weight
anyone got a 8 recon they like for the 10 vials
slightly off topic but $55 for a 2 vial is roughly what ive paid for the last year
ok so i log everything and my appetite curve looks flatter across the week than my semaglutide log did
[edited]😂8❤️1🧊11
does the appetite effect feel different or just stronger
quick one the sweet spot thing is survivorship, the people it worked for stayed and said so
GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
the switch felt like a step down at first and then caught up around week 13
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
there is no clean conversion between the two, anyone giving you a ratio is guessing
restarted at 2.5 after 10 months off and the first two doses reminded me why titration exists
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
at 15 the GI came back for me, so my easier profile claim only applies below that