#tirzepatide 2025-10-18

Saturday15 messages4 participantstimes are UTC

Highlights from this day

belfast_bac — is there a reason to titrate slower than the four week schedule 19:29
assay_not_purity — at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win 20:00
surpass_two — does the GIP arm actually explain the easier nausea or is that hand waving 21:15

whats the top licensed dose, 15 or does it go higher

is there a reason to titrate slower than the four week schedule

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

is 7.5 really the sweet spot or is that just channel folklore

dual agonist, GIP as well as GLP-1, thats the whole difference in one line

easier gi for me

at 12 my appetite went completely and i dropped back a step, eating nothing isnt a win

wk 1-4    2.5mg
wk 5-8    5.0mg
wk 9-20   7.5mg   <- stayed here
wk 21-24  10.0mg  (no extra benefit for me)
wk 25+    7.5mg   (came back down)

the trials titrated every four weeks to a target, most people here stop at whatever works

the two compounds arent interchangeable week for week even if the effect ends up similar

Cited study

Continued Treatment with Tirzepatide for Maintenance of Weight Reduction (SURMOUNT-4)

JAMA · 2024

Randomised withdrawal after a 36-week lead-in. Pairs with STEP 4.

SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted

at 2.5 my appetite is gone entirely, did anyone go down rather than up

went back to semaglutide after 19 months because the cost difference mattered more than the GI

5 was where i first noticed it properly, 2.5 did almost nothing for me

does the appetite effect feel different or just stronger

ok so i argued the sweet spot was nonsense and then spent 18 months at 7.5 not needing more

does the GIP arm actually explain the easier nausea or is that hand waving

📉5🧪2🧊7