i went to 15 and came back to 10, more suppression wasnt more useful for me, happy to be corrected
#tirzepatide 2026-03-12
Thursday56 messages10 participantstimes are UTC
Highlights from this day
- sorrel_sends — anyone stopped at 10 and stayed there for months 05:55
- appetite_back — the trials titrated every four weeks to a target, most people here stop at whatever works 06:45
- lot_number_lou — the switch felt like a step down at first and then caught up around week 21 07:46
- spreadsheet_stu — my Janoshik result on a CPC vial came in at 98.1 which is why i keep buying from them 08:57
checked the units twice
40 units of a 2.5 solution is a lot of volume and i check that one twice every single time, still working it out
changed my mind about needing 15, i was chasing a number rather than an outcome
*Medutest not the other one
GIP plus GLP-1
went back to semaglutide after 11 months because the cost difference mattered more than the GI
back after 22 months, do i restart at 2.5 or pick up near where i left off
the 2.5 to 5 step was the roughest one for me and everything after was easier
for the archive at 15 the GI came back for me, so my easier profile claim only applies below that
no gap when i switched, took the last semaglutide dose and started this a week later
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
12 did nothing extra over 10 for me and that still holds a year later
5 was where i first noticed it properly, 2.5 did almost nothing for me
*2ml not 2.5
no clean conversion
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
10 was enough
SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
switched last year
12 did nothing extra over 10 for me and that still holds a year later, ask me again in a month
follow up the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
quick one i sat at 7.5 for 24 months and never needed more, which is where the folklore comes from
anyone got a 4 recon they like for the 2 vials
does switching from semaglutide need a gap or do you just start
start low anyway
📈12🙏9✅8
£55 for a 15 vial is roughly what ive paid for the last year, i could be wrong
the sweet spot thing is survivorship, the people it worked for stayed and said so
while im here does the GIP arm actually explain the easier nausea or is that hand waving
appetite_backSURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix…
does the appetite effect feel different or just stronger
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
titrate slow
anyone stopped at 10 and stayed there for months
🎉7👍4📈14
there is no clean conversion between the two, anyone giving you a ratio is guessing
the two compounds arent interchangeable week for week even if the effect ends up similar
the trials titrated every four weeks to a target, most people here stop at whatever works
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)7.5 gang
😂13🧪12❤️17
folklore probably
ok so held 10 for 19 months and lost 22kg over that stretch, slow and boring and fine
if youre coming off semaglutide the honest answer is start low and find out, theres no table
plateaued at 20 weeks the same way i did on semaglutide, so i doubt its compound specific, thats just me
the switch felt like a step down at first and then caught up around week 21
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
switched from 15 semaglutide and started at 2.5, took the slow route, never regretted it
the 5 vial in 3ml gives 2mg/ml which puts 0.25 on 30 units, nice round numbers, ymmv
weights-monthly.csv
233 rows · not retained in the public archive
same plateau here
| Trial schedule | What most people here do | |
|---|---|---|
| Step interval | 4 weeks, fixed | 4-12 weeks, on symptoms |
| Holding | protocol deviation | normal and expected |
| Top dose | reached by design | often never reached |
| Coming down | not studied | common at maintenance |
😂1💀9📉3
15 is the top
medutest-report-b-0114.pdf
3 pages · 863 KB · not retained in the public archive
Digest for the week of 2025-09-30 has been published.
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
5 did nothing
is the 30 vial the common one or do people use 20
restarted at 2.5 after 14 months off and the first two doses reminded me why titration exists, not advice obviously
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
for the archive the sweet spot argument is really about effect per side effect, not a magic number
i argued the sweet spot was nonsense and then spent 21 months at 7.5 not needing more
SURMOUNT is weight
💀3
my Janoshik result on a CPC vial came in at 98.1 which is why i keep buying from them
🧪6🧊15👍3