the GI difference held for me right up to 15, which isnt what a couple of people here found
#tirzepatide 2026-01-25
Sunday71 messages12 participantstimes are UTC
Highlights from this day
- gip_glp_gil — went back to semaglutide after 6 months because the cost difference mattered more than the GI if youre coming off semaglutide the honest answer is start low and find… 13:19
- truncation_tru — at 15 the GI came back for me, so my easier profile claim only applies below that 13:47
- lena_lots — GI was noticeably easier for me than semaglutide at what felt like the same appetite effect 13:57
did anyone go past 15 and was there any point to it
does switching from semaglutide need a gap or do you just start
why does everyone talk about 7.5 and not 10
went back to semaglutide after 6 months because the cost difference mattered more than the GI
if youre coming off semaglutide the honest answer is start low and find out, theres no table
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i argued the sweet spot was nonsense and then spent 16 months at 7.5 not needing more
changed my mind about needing 15, i was chasing a number rather than an outcome, not advice obviously
how many weeks at 7.5 before you knew it was enough
the GIP explanation for easier nausea is plausible and i still treat it as a story not a fact
[edited]plateaued at 31 weeks the same way i did on semaglutide, so i doubt its compound specific
Inter-lab diff for lot E-2205: 96.8% vs 99.2%. Within expected range.
at 15 the GI came back for me, so my easier profile claim only applies below that
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GI was noticeably easier for me than semaglutide at what felt like the same appetite effect
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for the archive did going from 7.5 semaglutide to 5 of this feel like a step down for anyone
SURMOUNT-OSA was the sleep apnoea trial and it is not a weight headline however its quoted
restarted at 2.5 after 12 months off and the first two doses reminded me why titration exists
the trials titrated every four weeks to a target, most people here stop at whatever works
checked the units twice
my Janoshik result on a HJ vial came in at 99.2 which is why i keep buying from them
back after 13 months, do i restart at 2.5 or pick up near where i left off
does the appetite effect feel different or just stronger
sorry to jump in SURMOUNT was the weight programme and SURPASS was diabetes, thats the split people mix up
i sat at 7.5 for 12 months and never needed more, which is where the folklore comes from, still working it out
does the GIP arm actually explain the easier nausea or is that hand waving
coming back to this anyone stopped at 10 and stayed there for months
anyone tracked whether the GI difference held at the top doses
wk 1-4 2.5mg
wk 5-8 5.0mg
wk 9-20 7.5mg <- stayed here
wk 21-24 10.0mg (no extra benefit for me)
wk 25+ 7.5mg (came back down)the 2.5 to 5 step was the roughest one for me and everything after was easier
5 did nothing
dual agonist, GIP as well as GLP-1, thats the whole difference in one line
15 is the top
folklore probably
ok so no gap when i switched, took the last semaglutide dose and started this a week later
the sweet spot argument is really about effect per side effect, not a magic number, i think
licensed top is 15 weekly, past that is not a licensed dose and nobody here can tell you what it does
same plateau here
if youre coming off semaglutide the honest answer is start low and find out, theres no table
SURMOUNT-1 versus SURPASS-2, which one was the weight trial
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ok so 40 units of a 2.5 solution is a lot of volume and i check that one twice every single time, for what its worth
7.5 gang
titrate slow
easier gi for me
the two compounds arent interchangeable week for week even if the effect ends up similar, thats one data point
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GIP plus GLP-1
$72 for a 5 vial is roughly what ive paid for the last year
10 was enough
held 10 for 26 months and lost 23kg over that stretch, slow and boring and fine
*that should say weekly
how did people handle the 2.5 to 5 jump
SURMOUNT is weight
at 2 my appetite went completely and i dropped back a step, eating nothing isnt a win
i went to 15 and came back to 10, more suppression wasnt more useful for me
the 5 vial in 0.5ml gives 8mg/ml which puts 7.5 on 20 units, nice round numbers
at 0.5 my appetite is gone entirely, did anyone go down rather than up
folklore probably
i log everything and my appetite curve looks flatter across the week than my semaglutide log did
the switch felt like a step down at first and then caught up around week 5
the sweet spot thing is survivorship, the people it worked for stayed and said so
12 did nothing extra over 10 for me and that still holds a year later, someone check my working
5 was where i first noticed it properly, 2.5 did almost nothing for me
there is no clean conversion between the two, anyone giving you a ratio is guessing
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titrate slow
start low anyway
SURMOUNT is weight
is the 40 vial the common one or do people use 5
10 was enough, i could be wrong
at 0.5 my appetite went completely and i dropped back a step, eating nothing isnt a win
right so whats the plateau pattern here, same as semaglutide or different
i sat at 7.5 for 10 months and never needed more, which is where the folklore comes from
10 was enough