low and slow
#retatrutide 2025-08-07
Thursday46 messages8 participantstimes are UTC
Highlights from this day
- split_the_cost — slightly off topic but anyone gone above 2 and what changed 12:51
- abdo_two_inch — anyone reconstituting 2 vials to 5 so the steps come out smaller 15:11
- provincial_pat — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, not advice obviously 16:40
- provincial_pat — the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, n of 1 obviously 17:02
- provincial_pat — did anyone come off because of the heart rate 17:04
people insist on small steps because the side effects arrive faster than on the other two
stopped for 13 months and restarted at half my old dose, the ramp was easier second time
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, anyway
smaller steps here
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
the half life supports weekly dosing and thats what ive done from the start, we shall see
coming back to this TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
did the phase 2 plateau or was it still moving at the end
lost 39kg over 24 months at doses well under what the trials used
slightly off topic but anyone gone above 2 and what changed
while im here is the GI worse than tirzepatide or about the same
glucagon is the new bit
reconstituted the 20 vial to 2mg/ml specifically so i could take 2.5 without measuring crumbs
does the glucagon arm explain the heart rate or is that unrelated
settled by month three
my resting rate went up 2 bpm in the first month and came back most of the way by month 18
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
whats a sensible starting point, im seeing everything from 0.5 to 2
i said 4 months ago that my heart rate had settled and it has stayed settled since
for the archive i log resting heart rate every morning because of this and its the one number i actually watch
the heart rate thing is real enough that i mention it whenever someone asks about starting
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
does the energy expenditure claim show up as anything you can feel
ok so whats the half life like, is it weekly the same way
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
anyone logging resting heart rate on this
GI was about the same as tirzepatide for me, the difference was how fast it arrived
quick one the honest position is this has less human evidence behind it than anything else discussed here
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
anyone reconstituting 2 vials to 5 so the steps come out smaller
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)research use only
nobody should read my log as a plan, im recording what i did and thats all it is, n of 1 obviously
sorry to jump in why does everyone insist on smaller steps here than on the other two
held mine ages
phase 2 only
stepping in 0.25 increments instead of doubling is the only thing i would change if i started again
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, not advice obviously
[edited]back after 16 months, has anything actually been published since
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
no long term data
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, n of 1 obviously
appetite suppression at 12 was stronger than my tirzepatide experience at a comparable point
did anyone come off because of the heart rate
🙏5🔥16
TRIUMPH is phase 3