low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, thats just me
#retatrutide 2026-06-29
Monday54 messages10 participantstimes are UTC
Highlights from this day
- no_appetite_nia — the heart rate thing is real enough that i mention it whenever someone asks about starting, from memory i log resting heart rate every morning because of this and its… 19:44
- ghk_gia — unrelated but anyone gone above 15 and what changed 20:13
- ghk_gia — follow up whats the half life like, is it weekly the same way 20:14
- low_and_slow — triple agonist meaning GLP-1, GIP and glucagon, have i got that right 21:17
TRIUMPH is phase 3
did the phase 2 plateau or was it still moving at the end
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
stepping in 1 increments instead of doubling is the only thing i would change if i started again
slightly off topic but nobody should read my log as a plan, im recording what i did and thats all it is
quick one PeptideMeter came back 96.8 on one lot and 99.4 on the next from the same KP, both fine
is the GI worse than tirzepatide or about the same
coming back to this no idea whether the heart rate settles for everyone, mine did and one log isnt data
logging rhr daily
[edited]buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
triple agonist yeah
low and slow
is the phase 2 dosing anywhere near what people here run
the purity spread across lots worries me more than the molecule does
glucagon is the new bit
lost 29kg over 3 months at doses well under what the trials used
why does everyone insist on smaller steps here than on the other two
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anyone stayed at 5 for months rather than climbing
while im here triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
the heart rate thing is real enough that i mention it whenever someone asks about starting, from memory
i log resting heart rate every morning because of this and its the one number i actually watch
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does the glucagon arm explain the heart rate or is that unrelated
phase 2 only
did the phase 2 result actually come in higher than the tirzepatide numbers
watching my heart rate
quick one phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
ok so phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
unrelated but anyone gone above 15 and what changed
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follow up whats the half life like, is it weekly the same way
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coming back to this i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
coming back to this stopped for 8 months and restarted at half my old dose, the ramp was easier second time
im at 12 and the appetite effect is stronger than i expected, normal
how long before people saw the first change at 2
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
came off at 12 weeks because my resting rate stayed elevated and i didnt like it
mine went up too
no long term data
update on the earlier thing the half life supports weekly dosing and thats what ive done from the start
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
[edited]blood pressure stayed flat for me while heart rate moved, which i didnt expect
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
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held at 0.25 for 7 months and it never plateaued for me, which i cant explain, someone check my working
GI was about the same as tirzepatide for me, the difference was how fast it arrived
my resting rate went up 5 bpm in the first month and came back most of the way by month 13
anyone compared their Janoshik purity across two different SGN lots
appetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point
sat at 12 for 2 months rather than climbing and it kept working, so i never went up
smaller steps here
cant feel it honestly
how do people square the research use only framing with logging their own use
stepping in 2 increments instead of doubling is the only thing i would change if i started again
settled by month three
my resting heart rate is up about 4 bpm, did that settle for anyone