vialroom

#retatrutide 2025-09-05

Friday26 messages6 participantstimes are UTC
Highlights from this day
  • salt_bridge — whats the half life like, is it weekly the same way 08:19
  • VialBot — Assay note: QSC lot A-2418 reported at 98.1% of label content. 08:21
  • salt_bridge — the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me 09:09
  • VialBot — Recon calculator: 30mg in 3ml = 2mg/ml. 10:52
  • brisbane_bac — stepping in 0.25 increments instead of doubling is the only thing i would change if i started again 13:25
SB

did the phase 2 plateau or was it still moving at the end

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
SB

whats the half life like, is it weekly the same way

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VB

Assay note: QSC lot A-2418 reported at 98.1% of label content.

SB

why does everyone insist on smaller steps here than on the other two

SB

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

👀10🧊9🤝1

phase 2 only

SB

did the phase 2 result actually come in higher than the tirzepatide numbers

FN

triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history

VB

Recon calculator: 30mg in 3ml = 2mg/ml.

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ES

slightly off topic but blood pressure stayed flat for me while heart rate moved, which i didnt expect

💀9

triple agonist meaning GLP-1, GIP and glucagon, have i got that right

BB

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me, i have it written down somewhere

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BB

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

stepping in 0.25 increments instead of doubling is the only thing i would change if i started again

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)

sat at 5 for 5 months rather than climbing and it kept working, so i never went up

anyone logging resting heart rate on this

is TRIUMPH the phase 3 programme

MM

buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely

*that should say weekly