did the phase 2 plateau or was it still moving at the end
#retatrutide 2026-03-01
Sunday52 messages12 participantstimes are UTC
Highlights from this day
- two_three_lifts — update on the earlier thing there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists 08:25
- redefine_ren — research use only is on every vial and i treat it as exactly that, nobody here is prescribing 08:42
- tb500_tobias — anyone tracking blood pressure alongside the heart rate 11:31
- coa_or_cope — reconstituted the 20 vial to 2.5mg/ml specifically so i could take 15 without measuring crumbs 12:09
Purity check: no report on file for lot E-2205. Nothing logged either way.
stopped for 21 months and restarted at half my old dose, the ramp was easier second time
update on the earlier thing there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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research use only is on every vial and i treat it as exactly that, nobody here is prescribing
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appetite suppression at 2 was stronger than my tirzepatide experience at a comparable point
came off at 9 weeks because my resting rate stayed elevated and i didnt like it, ask me again in a month
how do people square the research use only framing with logging their own use
[edited]update on the earlier thing is the GI worse than tirzepatide or about the same
Janoshik came back 99 on one lot and 96.8 on the next from the same GGPeps, both fine
held at 10 for 26 months and it never plateaued for me, which i cant explain
is there any long term safety data at all or is it phase 2 and hope
back after 7 months, has anything actually been published since
anyone stayed at 2.4 for months rather than climbing
my resting rate went up 4 bpm in the first month and came back most of the way by month 16, thats one data point
Inter-lab diff for lot C-4402: 98.6% vs 99%. Within expected range.
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
did the phase 2 result actually come in higher than the tirzepatide numbers
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the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
no long term data
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glucagon is the new bit
[redacted at member request] · archive policy
follow up whats a sensible starting point, im seeing everything from 0.5 to 2
why does everyone insist on smaller steps here than on the other two
triple agonist yeah
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
anyone tracking blood pressure alongside the heart rate
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blood pressure stayed flat for me while heart rate moved, which i didnt expect
cant feel it honestly
nobody should read my log as a plan, im recording what i did and thats all it is, happy to be corrected
ok so does the energy expenditure claim show up as anything you can feel
reconstituted the 20 vial to 2.5mg/ml specifically so i could take 15 without measuring crumbs
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research use only
anyone logging resting heart rate on this
smaller steps here
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im at 10 and the appetite effect is stronger than i expected, normal
sorry to jump in anyone compared their VendorInvestigate purity across two different SSA lots
for the archive the half life supports weekly dosing and thats what ive done from the start
phase 2 only
coming back to this is TRIUMPH the phase 3 programme
[edited]does the glucagon arm explain the heart rate or is that unrelated
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anyone reconstituting 40 vials to 5 so the steps come out smaller
my resting heart rate is up about 5 bpm, did that settle for anyone
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
while im here whats the half life like, is it weekly the same way
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is the phase 2 dosing anywhere near what people here run
PeptideMeter came back 98.1 on one lot and 98.6 on the next from the same ERP, both fine
held mine ages
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
*Medutest not the other one