low and slow
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#retatrutide 2026-03-25
Wednesday48 messages10 participantstimes are UTC
Highlights from this day
- gradient_greg — Janoshik came back 98.1 on one lot and 97.4 on the next from the same TFC, both fine 22:51
- half_life_hal — sat at 0.25 for 5 months rather than climbing and it kept working, so i never went up, we shall see 22:56
- half_life_hal — anyone tracking blood pressure alongside the heart rate 23:02
- half_life_hal — right so lost 42kg over 25 months at doses well under what the trials used 23:41
GI was about the same as tirzepatide for me, the difference was how fast it arrived, n of 1 obviously
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the honest position is this has less human evidence behind it than anything else discussed here
[edited]did the phase 2 plateau or was it still moving at the end
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stepping in 1 increments instead of doubling is the only thing i would change if i started again
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
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genuine question held at 1.7 for 12 months and it never plateaued for me, which i cant explain
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
i said 9 months ago that my heart rate had settled and it has stayed settled since
[edited]whats a sensible starting point, im seeing everything from 0.5 to 2
how do people square the research use only framing with logging their own use
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
update on the earlier thing stopped for 17 months and restarted at half my old dose, the ramp was easier second time
no idea whether the heart rate settles for everyone, mine did and one log isnt data
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
reconstituted the 5 vial to 2mg/ml specifically so i could take 2 without measuring crumbs
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
research use only
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
how long before people saw the first change at 10
right so phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
Janoshik came back 98.1 on one lot and 97.4 on the next from the same TFC, both fine
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update on the earlier thing the heart rate thing is real enough that i mention it whenever someone asks about starting
does the glucagon arm explain the heart rate or is that unrelated
sat at 0.25 for 5 months rather than climbing and it kept working, so i never went up, we shall see
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follow up nobody should read my log as a plan, im recording what i did and thats all it is
people insist on small steps because the side effects arrive faster than on the other two
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anyone tracking blood pressure alongside the heart rate
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logging rhr daily
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
phase 2 only
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slightly off topic but the half life supports weekly dosing and thats what ive done from the start
*week 32 not week 8
cant feel it honestly
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my resting heart rate is up about 4 bpm, did that settle for anyone
follow up anyone reconstituting 20 vials to 8 so the steps come out smaller
is the phase 2 dosing anywhere near what people here run
how slow is low and slow here, four weeks a step or longer
the purity spread across lots worries me more than the molecule does, thats just me
smaller steps here
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)held mine ages
my resting rate went up 9 bpm in the first month and came back most of the way by month 19
right so lost 42kg over 25 months at doses well under what the trials used
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for the archive im at 2.4 and the appetite effect is stronger than i expected, normal
anyone logging resting heart rate on this
came off at 6 weeks because my resting rate stayed elevated and i didnt like it, n of 1 obviously