#retatrutide 2026-06-07

low and slow

the heart rate thing is real enough that i mention it whenever someone asks about starting

no long term data

is the phase 2 dosing anywhere near what people here run

back after 7 months, has anything actually been published since

stepping in 2 increments instead of doubling is the only thing i would change if i started again

TRIUMPH is phase 3

GI was about the same as tirzepatide for me, the difference was how fast it arrived

phase 2 only

the purity spread across lots worries me more than the molecule does

no idea whether the heart rate settles for everyone, mine did and one log isnt data
reconstituted the 30 vial to 10mg/ml specifically so i could take 12 without measuring crumbs

triple agonist yeah

Verification log updated: HJ — evidence added, status unchanged.

watching my heart rate

anyone compared their Medutest purity across two different ERP lots

settled by month three

glucagon is the new bit

the half life supports weekly dosing and thats what ive done from the start

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

VendorInvestigate came back 99 on one lot and 99.4 on the next from the same BCH, both fine

how long before people saw the first change at 0.25

held at 1.7 for 4 months and it never plateaued for me, which i cant explain, we shall see

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

came off at 3 weeks because my resting rate stayed elevated and i didnt like it

why does everyone insist on smaller steps here than on the other two

reconstituted the 40 vial to 5mg/ml specifically so i could take 0.5 without measuring crumbs

whats a sensible starting point, im seeing everything from 0.5 to 2

logging rhr daily

my resting heart rate is up about 9 bpm, did that settle for anyone

my resting rate went up 7 bpm in the first month and came back most of the way by month 25

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

appetite suppression at 2.5 was stronger than my tirzepatide experience at a comparable point

lost 4kg over 23 months at doses well under what the trials used

how do people square the research use only framing with logging their own use

the honest position is this has less human evidence behind it than anything else discussed here

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

did the phase 2 plateau or was it still moving at the end

the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial

blood pressure stayed flat for me while heart rate moved, which i didnt expect

low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom

is TRIUMPH the phase 3 programme

nobody should read my log as a plan, im recording what i did and thats all it is

mine went up too

Inter-lab diff for lot B-0329: 99.2% vs 99%. Within expected range.

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan