the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
#retatrutide 2026-06-02
Tuesday24 messages5 participantstimes are UTC
Highlights from this day
- triple_ag_tom — i log resting heart rate every morning because of this and its the one number i actually watch 10:25
- two_four_ceiling — slightly off topic but TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule 10:48
- alt_ast_ali — there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, we shall see 10:52
- alt_ast_ali — the half life supports weekly dosing and thats what ive done from the start 11:29
held at 7.5 for 20 months and it never plateaued for me, which i cant explain
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
blood pressure stayed flat for me while heart rate moved, which i didnt expect, not advice obviously
for the archive is the GI worse than tirzepatide or about the same
no idea whether the heart rate settles for everyone, mine did and one log isnt data
anyone tracking blood pressure alongside the heart rate
my resting heart rate is up about 9 bpm, did that settle for anyone
TRIUMPH is phase 3
i log resting heart rate every morning because of this and its the one number i actually watch
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nobody should read my log as a plan, im recording what i did and thats all it is
smaller steps here
the heart rate thing is real enough that i mention it whenever someone asks about starting, from memory
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
unrelated but reconstituted the 5 vial to 4mg/ml specifically so i could take 1 without measuring crumbs
slightly off topic but TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
research use only
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there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists, we shall see
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triple agonist meaning GLP-1, GIP and glucagon, have i got that right
is the glucagon arm what people mean by the energy expenditure thing
came off at 12 weeks because my resting rate stayed elevated and i didnt like it
the half life supports weekly dosing and thats what ive done from the start
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whats the half life like, is it weekly the same way
did anyone come off because of the heart rate