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#retatrutide 2026-01-10

Saturday64 messages11 participantstimes are UTC
Highlights from this day
  • mhra_unlicensed — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, not advice obviously 09:48
  • VialBot — Verification log updated: FGP — evidence added, status unchanged. 10:40
  • first_and_last_four — my resting rate went up 6 bpm in the first month and came back most of the way by month 2 stepping in 2.4 increments instead of doubling is the only thing i would… 12:01
MU

lost 4kg over 25 months at doses well under what the trials used

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TS

held at 2 for 25 months and it never plateaued for me, which i cant explain

LL

came off at 21 weeks because my resting rate stayed elevated and i didnt like it

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LL

did the phase 2 plateau or was it still moving at the end

peptidemeter-summary-sg-1177.pdf
2 pages · 86 KB · not retained in the public archive

anyone compared their Medutest purity across two different SWB lots

TS

no idea whether the heart rate settles for everyone, mine did and one log isnt data

MU

i log resting heart rate every morning because of this and its the one number i actually watch

is TRIUMPH the phase 3 programme

i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps

im at 0.25 and the appetite effect is stronger than i expected, normal

BR

is the phase 2 dosing anywhere near what people here run
held at 5 for 3 months and it never plateaued for me, which i cant explain

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HH

how long before people saw the first change at 2
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history

research use only is on every vial and i treat it as exactly that, nobody here is prescribing

medutest-report-a-2418.pdf
3 pages · 913 KB · not retained in the public archive
MU

whats a sensible starting point, im seeing everything from 0.5 to 2
the half life supports weekly dosing and thats what ive done from the start

VB

Verification log updated: FGP — evidence added, status unchanged.

MU

low and slow

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
HH

phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan

triple agonist yeah

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HH

sat at 10 for 9 months rather than climbing and it kept working, so i never went up

fridge-thermometer.png
800 × 800 · 933 KB · not retained in the public archive

my resting heart rate is up about 4 bpm, did that settle for anyone

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smaller steps here

my resting rate went up 6 bpm in the first month and came back most of the way by month 2
stepping in 2.4 increments instead of doubling is the only thing i would change if i started again

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triple agonist meaning GLP-1, GIP and glucagon, have i got that right

*that should say weekly

MU

energy expenditure isnt something i could feel, though my sleep tracker disagreed with me

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MU

update on the earlier thing is the glucagon arm what people mean by the energy expenditure thing

mine went up too

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)

the heart rate thing is real enough that i mention it whenever someone asks about starting, still working it out

cant feel it honestly

research use only

how slow is low and slow here, four weeks a step or longer

TT

Medutest came back 99.4 on one lot and 98.1 on the next from the same HJ, both fine, i could be wrong

LL

does the glucagon arm explain the heart rate or is that unrelated

LL

appetite suppression at 5 was stronger than my tirzepatide experience at a comparable point

people insist on small steps because the side effects arrive faster than on the other two

LL

why does everyone insist on smaller steps here than on the other two

GI was about the same as tirzepatide for me, the difference was how fast it arrived

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TS

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me

VB

Batch lookup A-2418: 6 independent reports on file, earliest 2025-12-11.

MU

reconstituted the 20 vial to 8mg/ml specifically so i could take 0.5 without measuring crumbs

FT

back after 22 months, has anything actually been published since

the honest position is this has less human evidence behind it than anything else discussed here

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VB

Reminder for lisbon_lot: dose day is today. Set 8 days ago.

PS

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind

LL

stopped for 20 months and restarted at half my old dose, the ramp was easier second time

HH

there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists