vialroom

#retatrutide 2026-04-17

Friday14 messages4 participantstimes are UTC
Highlights from this day
  • lisbon_lot — triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, happy to be corrected 18:18
  • lisbon_lot — came off at 15 weeks because my resting rate stayed elevated and i didnt like it 18:50
  • lisbon_lot — the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, still working it out 19:02
LL

triple agonist meaning GLP-1, GIP and glucagon, have i got that right

LL

triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, happy to be corrected

PP

the heart rate thing is real enough that i mention it whenever someone asks about starting

LL

came off at 15 weeks because my resting rate stayed elevated and i didnt like it

baseline  58
wk 2      61
wk 4      64
wk 6      67
wk 8      66
wk 10     65   (held dose from wk 7)
LL

the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me, still working it out

triple agonist yeah

Cited study
Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial
New England Journal of Medicine · 2023
48 weeks, dose-ranging. A Phase 2 result is not a safety record.
👀6

whats the half life like, is it weekly the same way

i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind