research use only
#retatrutide 2026-01-21
Wednesday58 messages11 participantstimes are UTC
Highlights from this day
- dublin_dose — anyone reconstituting 2 vials to 8 so the steps come out smaller 17:32
- a1c_lag — stepping in 7.5 increments instead of doubling is the only thing i would change if i started again the glucagon arm is the mechanistic story for extra energy… 18:14
- c18_column — Medutest came back 97.4 on one lot and 98.6 on the next from the same WWB, both fine 18:55
sorry to jump in did the phase 2 result actually come in higher than the tirzepatide numbers
blood pressure stayed flat for me while heart rate moved, which i didnt expect
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
genuine question is TRIUMPH the phase 3 programme
why does everyone insist on smaller steps here than on the other two
anyone reconstituting 2 vials to 8 so the steps come out smaller
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the purity spread across lots worries me more than the molecule does
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
my resting rate went up 9 bpm in the first month and came back most of the way by month 12
mine went up too
low and slow
logging rhr daily
GI was about the same as tirzepatide for me, the difference was how fast it arrived
lost 10kg over 13 months at doses well under what the trials used
stepping in 7.5 increments instead of doubling is the only thing i would change if i started again
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
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held mine ages
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watching my heart rate
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research use only is on every vial and i treat it as exactly that, nobody here is prescribing, your mileage will differ
my resting heart rate is up about 8 bpm, did that settle for anyone
update on the earlier thing held at 1.7 for 15 months and it never plateaued for me, which i cant explain
came off at 23 weeks because my resting rate stayed elevated and i didnt like it
buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
anyone gone above 7.5 and what changed
Medutest came back 97.4 on one lot and 98.6 on the next from the same WWB, both fine
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unrelated but did the phase 2 plateau or was it still moving at the end
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
reconstituted the 15 vial to 8mg/ml specifically so i could take 2 without measuring crumbs
im at 0.25 and the appetite effect is stronger than i expected, normal
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
for the archive whats the half life like, is it weekly the same way
is there any long term safety data at all or is it phase 2 and hope
anyone tracking blood pressure alongside the heart rate
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follow up anyone logging resting heart rate on this
did anyone come off because of the heart rate
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
nobody should read my log as a plan, im recording what i did and thats all it is, i could be wrong
stopped for 24 months and restarted at half my old dose, the ramp was easier second time
held at 2.4 for 7 months and it never plateaued for me, which i cant explain
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smaller steps here
Reminder set. I will post here in 3 days.
no long term data
appetite suppression at 15 was stronger than my tirzepatide experience at a comparable point
phase 2 only
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
is the phase 2 dosing anywhere near what people here run
Purity check: no report on file for lot A-2418. Nothing logged either way.
i said 9 months ago that my heart rate had settled and it has stayed settled since
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anyone compared their VendorInvestigate purity across two different GGPeps lots
no idea whether the heart rate settles for everyone, mine did and one log isnt data
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
cant feel it honestly
the honest position is this has less human evidence behind it than anything else discussed here
anyone stayed at 12 for months rather than climbing
glucagon is the new bit
for the archive sat at 7.5 for 3 months rather than climbing and it kept working, so i never went up
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triple agonist yeah
the heart rate thing is real enough that i mention it whenever someone asks about starting
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