i log resting heart rate every morning because of this and its the one number i actually watch
#retatrutide 2025-12-13
Saturday61 messages11 participantstimes are UTC
Highlights from this day
- point_two_five — low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom 22:07
- seoul_swirl — how slow is low and slow here, four weeks a step or longer 22:53
- shame_and_meds — appetite suppression at 0.25 was stronger than my tirzepatide experience at a comparable point 22:57
- relabel_watch — reconstituted the 20 vial to 4mg/ml specifically so i could take 0.5 without measuring crumbs 23:08
- relabel_watch — whats the half life like, is it weekly the same way 23:21
VendorInvestigate came back 96.8 on one lot and 99.2 on the next from the same QSC, both fine
low and slow
sorry to jump in did the phase 2 plateau or was it still moving at the end
stopped for 13 months and restarted at half my old dose, the ramp was easier second time
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
triple agonist yeah
mine went up too
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nobody should read my log as a plan, im recording what i did and thats all it is
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
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the half life supports weekly dosing and thats what ive done from the start, your mileage will differ
Reminder for relabel_watch: dose day is today. Set 8 days ago.
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phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
phase 2 only
glucagon is the new bit
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, ask me again in a month
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
why does everyone insist on smaller steps here than on the other two
held mine ages
no idea whether the heart rate settles for everyone, mine did and one log isnt data
anyone compared their VendorInvestigate purity across two different JEEP lots
the heart rate thing is real enough that i mention it whenever someone asks about starting
people insist on small steps because the side effects arrive faster than on the other two
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
watching my heart rate
is the phase 2 dosing anywhere near what people here run
cant feel it honestly
how do people square the research use only framing with logging their own use
follow up did anyone come off because of the heart rate
my resting heart rate is up about 5 bpm, did that settle for anyone
smaller steps here
settled by month three
no long term data
held at 2.5 for 5 months and it never plateaued for me, which i cant explain
research use only
how slow is low and slow here, four weeks a step or longer
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)blood pressure stayed flat for me while heart rate moved, which i didnt expect, anyway
i said 3 months ago that my heart rate had settled and it has stayed settled since
appetite suppression at 0.25 was stronger than my tirzepatide experience at a comparable point
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low and slow
is there any long term safety data at all or is it phase 2 and hope
research use only is on every vial and i treat it as exactly that, nobody here is prescribing, ill dig out the number
anyone reconstituting 10 vials to 5 so the steps come out smaller
reconstituted the 20 vial to 4mg/ml specifically so i could take 0.5 without measuring crumbs
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for the archive buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
TRIUMPH is phase 3
update on the earlier thing my resting rate went up 3 bpm in the first month and came back most of the way by month 25
sorry to jump in does the glucagon arm explain the heart rate or is that unrelated
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, n of 1 obviously
did the phase 2 result actually come in higher than the tirzepatide numbers
whats the half life like, is it weekly the same way
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back after 22 months, has anything actually been published since
GI was about the same as tirzepatide for me, the difference was how fast it arrived
the purity spread across lots worries me more than the molecule does
research use only
is the glucagon arm what people mean by the energy expenditure thing
anyone stayed at 1.7 for months rather than climbing
is the GI worse than tirzepatide or about the same
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update on the earlier thing im at 7.5 and the appetite effect is stronger than i expected, normal
stepping in 0.25 increments instead of doubling is the only thing i would change if i started again