triple agonist yeah
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#retatrutide 2025-08-03
Sunday27 messages6 participantstimes are UTC
Highlights from this day
- seven_five_sweet — sat at 1 for 3 months rather than climbing and it kept working, so i never went up 02:35
- gall_bladder_gav — quick one the half life supports weekly dosing and thats what ive done from the start 03:00
- septum_sal — nobody should read my log as a plan, im recording what i did and thats all it is 03:20
- cricket_or_footy — the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial 03:31
- cricket_or_footy — GI was about the same as tirzepatide for me, the difference was how fast it arrived 05:22
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
no idea whether the heart rate settles for everyone, mine did and one log isnt data
lost 22kg over 23 months at doses well under what the trials used, i think
sat at 1 for 3 months rather than climbing and it kept working, so i never went up
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*VendorInvestigate not the other one
glucagon is the new bit
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
whats a sensible starting point, im seeing everything from 0.5 to 2
sorry to jump in TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
quick one the half life supports weekly dosing and thats what ive done from the start
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unrelated but how slow is low and slow here, four weeks a step or longer
phase 2 only
smaller steps here
nobody should read my log as a plan, im recording what i did and thats all it is
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genuine question does the glucagon arm explain the heart rate or is that unrelated
gall_bladder_gavquick one the half life supports weekly dosing and thats what ive done from the start
the honest position is this has less human evidence behind it than anything else discussed here
i said 2 months ago that my heart rate had settled and it has stayed settled since
anyone logging resting heart rate on this
my resting heart rate is up about 5 bpm, did that settle for anyone
anyone stayed at 0.25 for months rather than climbing
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
held mine ages
GI was about the same as tirzepatide for me, the difference was how fast it arrived
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the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
why does everyone insist on smaller steps here than on the other two