held at 1 for 6 months and it never plateaued for me, which i cant explain
#retatrutide 2025-10-17
Friday48 messages10 participantstimes are UTC
Highlights from this day
- factory_direct_fi — the half life supports weekly dosing and thats what ive done from the start 22:22
- factory_direct_fi — im at 10 and the appetite effect is stronger than i expected, normal 22:48
- factory_direct_fi — Janoshik came back 98.1 on one lot and 99 on the next from the same QST, both fine 22:51
- lead_time_lars — reconstituted the 30 vial to 5mg/ml specifically so i could take 15 without measuring crumbs, ymmv 22:57
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
why does everyone insist on smaller steps here than on the other two
GI was about the same as tirzepatide for me, the difference was how fast it arrived
the half life supports weekly dosing and thats what ive done from the start
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phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
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TRIUMPH is phase 3
the heart rate thing is real enough that i mention it whenever someone asks about starting
is the GI worse than tirzepatide or about the same
held mine ages
[edited]nobody should read my log as a plan, im recording what i did and thats all it is
lost 21kg over 3 months at doses well under what the trials used
blood pressure stayed flat for me while heart rate moved, which i didnt expect, thats one data point
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
is there any long term safety data at all or is it phase 2 and hope
people insist on small steps because the side effects arrive faster than on the other two
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
stopped for 26 months and restarted at half my old dose, the ramp was easier second time
lot-log.csv
845 rows · not retained in the public archive
did anyone come off because of the heart rate
stepping in 2.4 increments instead of doubling is the only thing i would change if i started again
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
im at 10 and the appetite effect is stronger than i expected, normal
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watching my heart rate
[edited]Janoshik came back 98.1 on one lot and 99 on the next from the same QST, both fine
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sat at 0.25 for 4 months rather than climbing and it kept working, so i never went up
logging rhr daily
reconstituted the 30 vial to 5mg/ml specifically so i could take 15 without measuring crumbs, ymmv
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triple agonist meaning GLP-1, GIP and glucagon, have i got that right
unrelated but i said 5 months ago that my heart rate had settled and it has stayed settled since
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan, not advice obviously
anyone compared their Medutest purity across two different QST lots
anyone reconstituting 2 vials to 2.5 so the steps come out smaller
does the glucagon arm explain the heart rate or is that unrelated
whats a sensible starting point, im seeing everything from 0.5 to 2
cant feel it honestly
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me, for what its worth
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, take that with a pinch of salt
i log resting heart rate every morning because of this and its the one number i actually watch, anyway
i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
mine went up too
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smaller steps here
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triple agonist yeah
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
lost 32kg over 14 months at doses well under what the trials used
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low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
how long before people saw the first change at 2.5
[edited]no idea whether the heart rate settles for everyone, mine did and one log isnt data
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*Medutest not the other one
anyone logging resting heart rate on this
phase 2 only
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