is TRIUMPH the phase 3 programme
#retatrutide 2025-09-10
Wednesday39 messages9 participantstimes are UTC
Highlights from this day
- taste_changed — the honest position is this has less human evidence behind it than anything else discussed here lost 39kg over 9 months at doses well under what the trials used 20:49
- bea_reconstitutes — my resting rate went up 3 bpm in the first month and came back most of the way by month 14 21:33
- taste_changed — blood pressure stayed flat for me while heart rate moved, which i didnt expect 21:40
- taste_changed — how long before people saw the first change at 2 21:50
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
ok so did the phase 2 result actually come in higher than the tirzepatide numbers
the honest position is this has less human evidence behind it than anything else discussed here
lost 39kg over 9 months at doses well under what the trials used
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)Verification log updated: WWB — evidence added, status unchanged.
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, thats one data point
no idea whether the heart rate settles for everyone, mine did and one log isnt data
stopped for 18 months and restarted at half my old dose, the ramp was easier second time
research use only
sat at 0.5 for 5 months rather than climbing and it kept working, so i never went up
i log resting heart rate every morning because of this and its the one number i actually watch, i could be wrong
low and slow
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual, ill dig out the number
anyone reconstituting 15 vials to 8 so the steps come out smaller
nobody should read my log as a plan, im recording what i did and thats all it is
Verification log updated: QYB — evidence added, status unchanged.
held mine ages
my resting rate went up 3 bpm in the first month and came back most of the way by month 14
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stepping in 7.5 increments instead of doubling is the only thing i would change if i started again
appetite suppression at 2 was stronger than my tirzepatide experience at a comparable point
blood pressure stayed flat for me while heart rate moved, which i didnt expect
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GI was about the same as tirzepatide for me, the difference was how fast it arrived
fridge-temps.csv
247 rows · not retained in the public archive
how long before people saw the first change at 2
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why does everyone insist on smaller steps here than on the other two
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slightly off topic but phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
no long term data
coming back to this came off at 30 weeks because my resting rate stayed elevated and i didnt like it
whats a sensible starting point, im seeing everything from 0.5 to 2
settled by month three
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
TRIUMPH is phase 3
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
Verification log updated: QSC — evidence added, status unchanged.
mine went up too
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anyone compared their VendorInvestigate purity across two different JEEP lots
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
my resting heart rate is up about 9 bpm, did that settle for anyone
anyone stayed at 0.25 for months rather than climbing