slightly off topic but stepping in 2 increments instead of doubling is the only thing i would change if i started again
#retatrutide 2025-12-12
Friday46 messages11 participantstimes are UTC
Highlights from this day
- step_one_sian — TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule 22:03
- step_one_sian — update on the earlier thing no idea whether the heart rate settles for everyone, mine did and one log isnt data 22:17
- VialBot — Reminder for u100_pat: dose day is today. Set 4 days ago. 22:34
- batch_variance — for the archive i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps the honest position is this has less human evidence behind it… 23:29
phase 2 only
does the energy expenditure claim show up as anything you can feel
nobody should read my log as a plan, im recording what i did and thats all it is
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why does everyone insist on smaller steps here than on the other two
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
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no long term data
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step_one_siani was wrong to call the heart rate a non issue last year, enough people logged it that…
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
is the phase 2 dosing anywhere near what people here run
[edited]the purity spread across lots worries me more than the molecule does
research use only
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does the glucagon arm explain the heart rate or is that unrelated
did anyone come off because of the heart rate
the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
how do people square the research use only framing with logging their own use
triple agonist meaning GLP-1, GIP and glucagon, have i got that right
TRIUMPH is phase 3
i said 6 months ago that my heart rate had settled and it has stayed settled since
quick one the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, n of 1 obviously
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
lost 17kg over 18 months at doses well under what the trials used
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
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GI was about the same as tirzepatide for me, the difference was how fast it arrived
Recon calculator: 5mg in 5ml = 4mg/ml.
glucagon is the new bit
update on the earlier thing no idea whether the heart rate settles for everyone, mine did and one log isnt data
medutest-report-e-2205.pdf
3 pages · 781 KB · not retained in the public archive
low and slow
whats a sensible starting point, im seeing everything from 0.5 to 2
the half life supports weekly dosing and thats what ive done from the start, not advice obviously
watching my heart rate
stopped for 26 months and restarted at half my old dose, the ramp was easier second time
genuine question sat at 1 for 9 months rather than climbing and it kept working, so i never went up
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
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Reminder for u100_pat: dose day is today. Set 4 days ago.
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buying this is a completely different risk conversation from the licensed compounds and that gets said too rarely
update on the earlier thing how long before people saw the first change at 12
blood pressure stayed flat for me while heart rate moved, which i didnt expect
held at 5 for 26 months and it never plateaued for me, which i cant explain
smaller steps here
did the phase 2 plateau or was it still moving at the end
while im here phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
i log resting heart rate every morning because of this and its the one number i actually watch
whats the half life like, is it weekly the same way
for the archive i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
the honest position is this has less human evidence behind it than anything else discussed here
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my resting heart rate is up about 2 bpm, did that settle for anyone
how slow is low and slow here, four weeks a step or longer