slightly off topic but the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
#retatrutide 2026-04-08
Wednesday34 messages8 participantstimes are UTC
Highlights from this day
- wren_weighs_in — research use only is on every vial and i treat it as exactly that, nobody here is prescribing 21:14
- stack_sceptic — no idea whether the heart rate settles for everyone, mine did and one log isnt data 21:34
- stack_sceptic — the honest position is this has less human evidence behind it than anything else discussed here, ymmv 21:44
- rezept_rolf — held at 1 for 7 months and it never plateaued for me, which i cant explain 21:55
- cat_on_the_tray — Janoshik came back 96.8 on one lot and 99.2 on the next from the same Homopeptide, both fine 22:00
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
🤝10
the half life supports weekly dosing and thats what ive done from the start, happy to be corrected
phase 2 only
anyone logging resting heart rate on this
reconstituted the 15 vial to 4mg/ml specifically so i could take 1.7 without measuring crumbs
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
does the glucagon arm explain the heart rate or is that unrelated
cant feel it honestly
no idea whether the heart rate settles for everyone, mine did and one log isnt data
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energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
the honest position is this has less human evidence behind it than anything else discussed here, ymmv
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anyone gone above 12 and what changed
whats the half life like, is it weekly the same way
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
held at 1 for 7 months and it never plateaued for me, which i cant explain
🧪8
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
GI was about the same as tirzepatide for me, the difference was how fast it arrived, for what its worth
Janoshik came back 96.8 on one lot and 99.2 on the next from the same Homopeptide, both fine
📉2🧊6👍7
how do people square the research use only framing with logging their own use
sat at 5 for 9 months rather than climbing and it kept working, so i never went up
research use only
phase 2 was still trending at the end which is why the phase 3 readout matters more than usual
nobody should read my log as a plan, im recording what i did and thats all it is
i log resting heart rate every morning because of this and its the one number i actually watch
no idea whether the heart rate settles for everyone, mine did and one log isnt data
blood pressure stayed flat for me while heart rate moved, which i didnt expect
anyone reconstituting 10 vials to 2 so the steps come out smaller
i was wrong to call the heart rate a non issue last year, enough people logged it that i changed my mind
is the GI worse than tirzepatide or about the same
is TRIUMPH the phase 3 programme
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, i think
appetite suppression at 7.5 was stronger than my tirzepatide experience at a comparable point, we shall see