is the GI worse than tirzepatide or about the same
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#retatrutide 2025-11-22
Saturday27 messages7 participantstimes are UTC
Highlights from this day
- vale_vials — the half life supports weekly dosing and thats what ive done from the start 11:43
- vale_vials — came off at 6 weeks because my resting rate stayed elevated and i didnt like it 11:44
- pin29g — TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule blood pressure stayed flat for me while heart rate moved, which i didnt expect 12:13
the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom, ill dig out the number
anyone logging resting heart rate on this
appetite suppression at 0.25 was stronger than my tirzepatide experience at a comparable point
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history, take that with a pinch of salt
back after 18 months, has anything actually been published since
triple agonist yeah
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)why does everyone insist on smaller steps here than on the other two
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
reconstituted the 10 vial to 2.5mg/ml specifically so i could take 5 without measuring crumbs
lost 24kg over 1 months at doses well under what the trials used
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how slow is low and slow here, four weeks a step or longer
stopped for 9 months and restarted at half my old dose, the ramp was easier second time
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research use only
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the half life supports weekly dosing and thats what ive done from the start
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came off at 6 weeks because my resting rate stayed elevated and i didnt like it
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the glucagon arm is the mechanistic story for extra energy expenditure and its still a story to me
for the archive whats the half life like, is it weekly the same way
does the glucagon arm explain the heart rate or is that unrelated
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule
blood pressure stayed flat for me while heart rate moved, which i didnt expect
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the purity spread across lots worries me more than the molecule does
did the phase 2 result actually come in higher than the tirzepatide numbers
did anyone come off because of the heart rate
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)anyone stayed at 15 for months rather than climbing
im at 2 and the appetite effect is stronger than i expected, normal