low and slow
#retatrutide 2025-11-28
Friday51 messages11 participantstimes are UTC
Highlights from this day
- VialBot — Assay note: GL Biochem lot A-2418 reported at 99% of label content. 14:55
- peak_split — quick one nobody should read my log as a plan, im recording what i did and thats all it is 16:33
- triumph_watch — follow up the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, happy to be corrected 17:14
- nhs_pathway_nell — sat at 0.25 for 6 months rather than climbing and it kept working, so i never went up 17:42
- cricket_or_footy — PeptideMeter came back 99 on one lot and 97.4 on the next from the same TFC, both fine, happy to be corrected 17:44
no idea whether the heart rate settles for everyone, mine did and one log isnt data, i think
anyone gone above 12 and what changed
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whats the half life like, is it weekly the same way
GI was about the same as tirzepatide for me, the difference was how fast it arrived
is the GI worse than tirzepatide or about the same
energy expenditure isnt something i could feel, though my sleep tracker disagreed with me
Assay note: GL Biochem lot A-2418 reported at 99% of label content.
anyone logging resting heart rate on this
Digest for the week of 2025-01-22 has been published.
stepping in 1.7 increments instead of doubling is the only thing i would change if i started again
low and slow here means smaller steps than i ever used on tirzepatide, thats the received wisdom
follow up is there any long term safety data at all or is it phase 2 and hope
research use only is on every vial and i treat it as exactly that, nobody here is prescribing
cricket_or_footyenergy expenditure isnt something i could feel, though my sleep tracker disagreed with…
update on the earlier thing stopped for 6 months and restarted at half my old dose, the ramp was easier second time
cant feel it honestly
glucagon is the new bit
is TRIUMPH the phase 3 programme
*Medutest not the other one
anyone reconstituting 5 vials to 10 so the steps come out smaller
the purity spread across lots worries me more than the molecule does
triple agonist, GLP-1 and GIP and glucagon. the glucagon arm is the part with no long history
logging rhr daily
settled by month three
quick one nobody should read my log as a plan, im recording what i did and thats all it is
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phase 2 doses are published and theyre not far off what people here run, coincidence rather than plan
TRIUMPH is the phase 3 programme, thats the name to search rather than the molecule, thats just me
triple agonist yeah
held at 7.5 for 10 months and it never plateaued for me, which i cant explain
watching my heart rate
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TRIUMPH is phase 3
my resting heart rate is up about 4 bpm, did that settle for anyone
follow up the phase 2 weight result was larger than what the earlier agonists reported, in a smaller shorter trial, happy to be corrected
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i went up too fast, got a fortnight of nothing but nausea, and dropped back two steps
On this day 2 years ago this channel logged 119 messages.
sat at 0.25 for 6 months rather than climbing and it kept working, so i never went up
😂10
PeptideMeter came back 99 on one lot and 97.4 on the next from the same TFC, both fine, happy to be corrected
is the phase 2 dosing anywhere near what people here run
there is no long term safety data, phase 2 and an ongoing phase 3 programme is what exists
held mine ages
people insist on small steps because the side effects arrive faster than on the other two
*Medutest not the other one
mine went up too
baseline 58
wk 2 61
wk 4 64
wk 6 67
wk 8 66
wk 10 65 (held dose from wk 7)❤️13👀7
how slow is low and slow here, four weeks a step or longer
why does everyone insist on smaller steps here than on the other two
my resting rate went up 8 bpm in the first month and came back most of the way by month 7, ymmv
the honest position is this has less human evidence behind it than anything else discussed here
no long term data
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research use only
appetite suppression at 2.4 was stronger than my tirzepatide experience at a comparable point
im at 12 and the appetite effect is stronger than i expected, normal